右美托咪定对脏器缺血／再灌注损伤的保护作用机制  

Protective effect of dexmedetomidine on organ ischemia/reperfusion injury

作　　者：郝楠楠[1] 陈晖[2] 雷志礼[2] 

机构地区：[1]徐州医学院江苏省麻醉学重点实验室&江苏省麻醉与镇痛应用技术重点实验室,221004 [2]武警总医院麻醉科

出　　处：《国际麻醉学与复苏杂志》2013年第10期909-913,共5页International Journal of Anesthesiology and Resuscitation

摘　　要：背景右美托咪定（dexmedetomidine，Dex）是一种新型高选择性α2-肾上腺素受体（alpha-2-adrenergic receptor，α2-AR）激动剂，Dex除具有镇静、镇痛、围术期交感阻滞的作用外，大量的研究表明Dex对多脏器的缺血，再灌注损伤（ischemia／reperfusion injury，I/RI）具有保护作用。目的综述国内外Dex对多脏器I／RI保护机制的研究进展，为Dex脏器保护机制的研究提供思路。内容Dex通过减轻再灌注过程中的氧化应激反应，降低炎性因子的表达，减少机体细胞凋亡，保护红细胞变形能力来发挥脏器保护作用。趋势随着Dex对多脏器I／RI的保护机制不断被阐明，将为其临床应用提供更为深入的理论基础。Background Dexmedetomidine （Dex） is a novel and highly selective alpha-2-adrenergic receptor（α2-AR） agonist with potent sedative, analgesic and sympatholytie properties. Many researches have proven its protective effect against organ ischemia/ repeffusion injury（I/RI）. Objective By summarizing researches domestic and overseas on the protective mechanism in multiple organ I/RI of Dex, we are trying to provide new ideas for further study. Content Dex alleviates the I/RI by decreasing lipid peroxidation, attenuating the inflammatory reactions, inhibiting the apoptosis and protecting erythroeyte deformability. Trend The protective mechanism of Dex in the case of I/RI should be further clarified to provide theoretical basis for further clinical application.

关 键 词：右美托咪定 α2-肾上腺素受体 缺血 再灌注损伤 

分 类 号：R614[医药卫生—麻醉学]