碳青霉烯耐药肠杆菌科细菌的监测与分析  

The monitoring and analysis of carbapenem-resistant Enterobacteriaceae

作　　者：姚燕[1] 余小春[2] 胡昌弟[1] 洪永富[1] 

机构地区：[1]浙江省常山县人民医院检验科,浙江常山324200 [2]浙江省常山县人民医院感染控制科,浙江常山324200

出　　处：《中国微生态学杂志》2013年第9期1095-1096,1098,共3页Chinese Journal of Microecology

摘　　要：目的调查某医院碳青霉烯耐药肠杆菌科细菌(carbapenem-resistant Enterobacteriaceae,CRE)的分布及耐药性。方法收集2010年至2012年、急诊和住院患者的细菌培养和药敏结果,对碳青霉烯耐药肠杆菌科细菌感染病例进行回顾性分析追踪。结果共检出碳青霉烯耐药肠杆菌科细菌9株,均来自ICU,阴沟肠杆菌5株,占55.6%,肺炎克雷伯菌3株,占33.3%,大肠埃希菌1株,占11.1%。药敏结果显示对复方新诺明、环丙沙星、哌拉西林/他唑巴坦的敏感率分别为55.7%、11.1%、11.1%,患者病情凶险,临床预后较差。结论为某医院多重耐药菌的预防控制,以及合理使用抗生素提供依据。Objective To investigate the distribution and drug resistance of carbapenem-resistant Enterobacteriaceae （CRE） in a hospital. Methods We collected the results of bacterial culture and sensitivity test of outpatients, emergency patients and inpatients from 2010 to 2012, and carried out retrospective analysis on the cases of carbapenem-resistant Enterobacteriaceae infection. Results We detected 9 carbapenem-resistant Enterobacteriaceae which were all from ICU, including 5 strains of Enterobacter cloacae, 3 strains of Kleb- siella pneumoniae, and 1 strain of Escherichia coli, accounting for 55.6% , 33.3. % and 11.1%, respectively. The results of susceptibil- ity tests showed that the antibiotic sensitivity rates against cotrimoxazole, ciprofloxacin and piperacillin/tazobactam were 55.7 %, 11.1% and 11.1%, respectively. Patients were in dangerous condition with poor clinical prognosis. Conclusion The results of this study can be used as a reference for the prevention and control of multi-drug resistant bacteria and rational use of antibiotics.

关 键 词：肠杆菌科细菌 碳青霉烯类 耐药性 

分 类 号：R378[医药卫生—病原生物学]