自制左心耳封堵器封闭犬左心耳后表面内皮化观察  

Endothelialization of self-made left atrial appendage occluder after implantation

作　　者：崔婷[1,2] 秦永文[1] 孙万峰[2] 

机构地区：[1]第二军医大学附属长海医院心血管内科,上海200433 [2]盐城市第三人民医院心血管内科,盐城224003

出　　处：《安徽医科大学学报》2013年第10期1256-1258,共3页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金面上项目(编号:81170150);上海市科委临床研究重点(编号:10441902102)

摘　　要：选用杂交犬14只,随机分为实验组10只和对照组4只。实验组使用自主研制的镍钛合金左心耳封堵器经房间隔穿刺途径行左心耳封堵,对照组手术步骤相同而不施行左心耳封堵。封堵后2、4、12周,实验组及对照组分批处死实验动物,进行大体及扫描电镜观察封堵器表面血栓及内皮细胞生长情况。结果显示实验组大体及电镜结果表明封堵器表面无血栓形成,内皮化在封堵后4周基本完成。Forteen hybrid dogs were randomly divided into experimental group （n = 10） and control group （n = 4）. The nickel-titanium shape memory alloy-made left atrial appendage occluder was implanted into the experimental dogs by transcatheter atrial septal puncture approach. While the control dogs underwent the same operation procedure and the occluder was not implanted. The experimental and the control dogs were killed in batches at 2, 4, and 12 weeks after occlusion. Gross examination and scanning electron microscopic were used to evaluale the adherence and growth of endothelial cells to the surface of the occluder. Gross and scanning electron microscopic observations showed that endothelialization on the occluder surface completed in the 4th week after occlusion.

关 键 词：左心耳封堵 镍钛记忆合金 内皮化 

分 类 号：R318[医药卫生—生物医学工程]