ATP结合盒转运子A1 R219K基因多态性与飞行员血脂异常的关系  

Relationship between ABCA1 R219K gene polymorphism and blood lipid abnormality in pilots

作　　者：罗丹[1] 冯戟[1] 马红雨[1] 董昭[1] 王婷 蔡庆[1] 

机构地区：[1]空军总医院临床检验中心 [2]解放军95830部队门诊部

出　　处：《武警医学》2013年第9期754-757,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的探讨三磷酸腺苷结合盒转运子(ABCA1)的R219K基因多态性与飞行员血脂的关系。方法 199例男性飞行员分为91例血脂异常组及108例血脂正常组(对照组),检测两组血脂及其他生化指标。PCR-RFLP方法测定两组ABCA1 R219K基因多态性。结果高血脂组与对照组ABCA1基因R219K基因型(RR、RK、KK)及等位基因频率(R、K)分别为28.6%、47.2%、24.2%、52.2%、47.8%,以及33.3%、53.7%、13.0%、60.2%、39.8%。两组基因型及等位基因频率差异无统计学意义(χ2=4.197,P=0.123;χ2=2.564,P=0.109)。高血脂组不同基因型的TC、TG、LDL-C差异均无统计学意义(分别为P=0.631,P=0.449,P=0.834)。而高血脂组携带KK基因型者HDL-C明显高于携带RR基因型者[(1.44±0.11)mmol/L vs(1.10±0.23)mmol/L,P<0.05]。结论检测ABCA1R219K基因型可为飞行员心、脑血管疾病的预防及个体化治疗提供新思路、新方法。Objective To investigate the relationship between ATP binding cassette transporter A1 （ ABCAI ） R219K gene polymorphism and blood lipid abnormality in pilots. Methods 199 male pilots were selected, including 91 hyperlipidemic patients and 108 healthy controls. ABCA1 R219K gene polymorphisms were determined by polymerase chain reaction restricted fragments length pol- ymorphism （ PCR - RFLP） , and blood lipids and other biochemical markers were also determined. Results The frequencies of the RR, RK, KK , allele R , allele K of ABCA1 R219K in hyperlipidemic group and control group were 28.6% , 47.2% , 24.2% , 52.2% , 47.8% and 33.3% , 53.7% , 13.0% , 60.2% , 39.8% , respectively. There were no significant differences in the genotype and allele frequencies of the R219K polymorphism between hyperlipidemic group and control group（x2 = 4. 197, P = 0. 123 and X2 = 2. 564, P =0. 109）. No significant differences in levels of TC, TC, LDL were observed among different genotypes of ABCA1 R219K in hyperlipidemic group （ P = 0. 631, P = 0. 449, P = 0. 834, respectively）. However, pilots with the KK genotype had significantly higher levels of high density lipoprotein - cholesterol （ HDL - C ） than those with the RR genotype in hyperlipidemic group （ 1.44± 0.11 mmol/L vs 1.10± 0.23 mmol/L, P 〈 0. 05 ）. Conclusions There are no significant differences in the genotype and allele frequencies of the R219K polymorphism between hyperlipidemie pilots and control pilots. The KK genotype of ABCA1 R219K polymorphism may be associated with significantly high HDL - C level in pilots.

关 键 词：飞行员 ABCA1 R219K 基因多态性 脂类 

分 类 号：R589.2[医药卫生—内分泌]