PAI-1基因4G/5G多态性与中老年女性高血压发病关系  

THE RELATIONSHIP BETWEEN PLASMINOGEN ACTIVATOR INHIBITOR 1GENE 4G/5GPOLYMORPHISMS AND HYPERTENSION IN MIDDLE-AGED WOMEN

作　　者：孙树凯[1] 翟玉娥[1] 郑红英[1] 李慧[1] 田清武[1] 

机构地区：[1]青岛大学医学院附属医院检验科,山东青岛266555

出　　处：《青岛大学医学院学报》2013年第6期542-543,545,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的观察纤溶酶原激活物抑制物-1(PAI-1)4G/5G基因多态性与中老年女性高血压发病的关系。方法选取142例无亲缘关系的初诊中老年女性高血压病人和152例年龄相匹配的健康女性作为对照,采用等位基因特异性PCR扩增技术进行基因型频率及等位基因分布频率的检测。结果对照组和高血压病人PAI-1 4G/4G、4G/5G和5G/5G基因型分布频率分别为32.9%、38.8%、28.3%和42.3%、36.6%和21.1%,两组间基因型分布频率比较差异无显著性(P>0.05);对照组和高血压病人PAI-1 4G和5G等位基因分布频率分别为52.3%、47.7%和60.6%、39.4%,两组PAI-1 4G等位基因分布频率比较差异有显著性(χ2=4.072,P<0.05)。结论中老年女性高血压病人PAI-1 4G等位基因分布频率显著增高,提示PAI-1 4G/5G基因多态性可能与中老年女性高血压遗传易感性有关。Objective To investigate the association of PAI-1 4G/5G polymorphisms with hypertension in middle-aged women. Methods In this study, 142 middle-aged women with hypertension at first visit and 152 age-matched healthy women were recruited. Anele-specific PCR amplification technique was applied to detect genotype frequency and alleles distribution frequen- cy. Results The genotype frequencies of 4G/4G, 4G/SG and 5G/SG in the patients and normal controls were 32.9%, 38.8% and 28.3% and 42.3%, 36.6% and 21.1%, respectively, the differences between the two groups were not significant （P〈0.05） ; 4G and 5G allele frequencies in the normal controls were 52.3 % and 47.7 %, and that in the patients were 60.6 % and 39.4 %, the differences between the two groups being significant （X2 =4.072,P〈0.05）. Conclusion PAI 1 4G allele frequency is signifi- cantly high in middle-aged women with hypertension, indicating that the PAI-1 4G/SG polymorphisms is probably associated with genetic susceptibility of hypertension in this age-group women.

关 键 词：纤溶酶原激活物抑制物1 多态性 单核苷酸 高血压 女(雌)性 

分 类 号：R544.1[医药卫生—心血管疾病]