电针在术中改善CO_2气腹应激损伤的临床研究  

Electroacupuncture for Improving the CO_2 Pneumoperitoneum Stress Injury during Surgery

作　　者：张翮[1] 王兰[1] 张敏[1] 陈彤宇[1] 吴晓珲[1] 陈静[1] 鲍丹[1] 沈卫东[1] 

机构地区：[1]上海中医药大学附属曙光医学院,上海201203

出　　处：《针灸临床杂志》2013年第8期30-35,共6页Journal of Clinical Acupuncture and Moxibustion

基　　金：上海市科学技术委员会科研计划项目;编号:12401903204;上海市卫生局中医药科研基金课题;编号:2010QL010A

摘　　要：目的:通过检测术中胃粘膜CO2分压、胃粘膜ph值、白介素-2和表皮生长因子的变化,观察电针对术中CO2气腹应激损伤的改善效果。方法:收治妇科腹腔镜手术病人60例,行随机、单盲、对照的临床试验。病人分为两组,I组30例,施以常规全身麻醉;Ⅱ组30例,在常规全身麻醉基础上,复合穴位电针,从进入手术室开始一直持续到手术结束。在不同时间点获取反映CO2气腹应激损伤的相关数据,以备评价所用。结果:胃粘膜CO2分压、胃粘膜ph值、白介素-2和表皮生长因子的组间、组内数值变化均存在显著差异(P<0.01)。结论:电针应用在全麻妇科腹腔镜手术中,能够保证胃粘膜的血氧供应,防止胃粘膜局部缺血或低灌注,维持胃黏膜屏障的生理功能,达到减轻CO2气腹对机体应激损伤的临床效果。Objective： By detecting intraoperative gastric mucosal CO 2 partial pressure,the gastric ph value,interleukin-2 and epidermal growth factor changes in order to observe improvement effect of electroacupuncture on the CO 2 pneumoperitoneum intraoperative stress injury.Methods： 60 cases of gynecologic laparoscopic surgery,the patient admitted,line randomized,single-blind,controlled clinical trial.The patients were divided into two groups,30 patients in I group subjected to conventional general anesthesia,30 patients in II group were on the basis of conventional general anesthesia,composite point acupuncture from entering the operating room had been continued until the end of surgery.Reflect the CO 2 pneumoperitoneum stress injury related data,obtain at different time points used for evaluation.Results： Compared with different groups,according to gastric CO 2 partial pressure,gastric ph value,interleukin-2 and epidermal growth factor,there were significant differences（P 0.01）.Conclusion： The application of electroacupuncture in gynecological laparoscopic surgery,anesthesia,can guarantee the oxygen supply of the gastric mucosa to prevent gastric mucosal ischemia or hypoperfusion,maintaining the physiological function of the gastric mucosal barrier,to alleviate CO 2 pneumoperitoneum stress injury.

关 键 词：电针 CO2气腹 胃粘膜CO2分压 胃粘膜PH值 白介素-2 表皮生长因子 

分 类 号：R245.97[医药卫生—针灸推拿学]