细胞间黏附分子-1基因K469E多态性与新疆维吾尔族人群冠心病的相关性研究  

Association between intercellular adhesion molecule-1 K469E polymorphism and coronary heart disease in people with Uygur ethnicity, in Xinjiang

作　　者：罗俊一[1] 马依彤[1] 谢翔[1] 杨毅宁[1] 马翔[1] 付真彦[1] 李晓梅[1] 于子翔[1] 陈邦党 刘芬 

机构地区：[1]新疆医科大学第一附属医院心脏中心,乌鲁木齐830054 [2]乌鲁木齐市心血管病重点实验室

出　　处：《中华流行病学杂志》2013年第10期1018-1022,共5页Chinese Journal of Epidemiology

基　　金：新疆维吾尔自治区科技支撑计划（201233138）

摘　　要：目的探讨细胞间黏附分子-1基因K469E位点在新疆维吾尔（维）族人群中的分布特点及与冠心病的相关性。方法应用聚合酶链反应-限制性片段长度多态性方法对新疆地区维族245例冠心病患者和377例健康受试者细胞间黏附分子基因-1第6外显子K469E位点进行基因型分析。结果冠心病组与对照组基因型分布均符合Hardy—Weinberg平衡（P〉0．05）。冠心病组与对照组中3种基因型分布的差异有统计学意义（P=0．039），K与E等位基因分布的差异也有统计学意义（P=0．031）；在男性亚组中冠心病组与对照组3种基因型分布的差异有统计学意义（P=0．029），等位基因分布差异均有统计学意义（P=0．025）；在女性亚组中基因型及等位基因分布的差异均无统计学意义。经调整混杂因素后，logistic回归分析提示KK基因型为维族男性人群冠心病发生的危险因素（OR=2．389，95％CI：1．458～3．915，P=0．001）。结论细胞间黏附分子-1基因第6外显子K469E基因多态性和新疆维族男性冠心病的发生具有相关性，KK基因型是冠心病发生的危险因素。Objective To explore the distribution on K469E single nucleotide polymorphism of ICAM-1 gene among people with Uygur ethnicity, in Xinjiang and to analyze the correlation between ICAM-1 gene polymorphism and coronary heart disease. Methods 245 patients with coronary heart disease patients and 377 healthy controls in Xinjiang Uygur population were studied. ICAM-1 gene K469E genotype located in exon 6 were detected by polymerase chain reaction-restricted fragments length polymorphism. Results Distribution of genotypes in the two groups appeared to be in Hardy-Weinberg equilibrium （P〉0.05）. The distribution of genotypes showed significant difference between the two groups （P=0.039） and the distributions of K and E allele also presented statistically significant difference （P=0.031）. Significant difference was also observed in males （P=0.029 for genotype, P=0.025 for allele） but not in females. After adjusted for confounding factors, results from logistic regression analysis indicated that KK genotype was a risk factor for CHD in Uygur male population （OR=2.389, 95% CI： 1.458-3.915, P=0.001）. Conclusion Genetic polymorphism of ICAM-1 K469E might increase the risk for coronary artery disease in males of Uygur patients in Xinjiang.

关 键 词：冠心病 细胞间黏附分子-1 单核苷酸多态性 维吾尔族 

分 类 号：R541.4[医药卫生—心血管疾病]