过氧化物酶体增殖物激活受体多态性及其单体型对C反应蛋白的影响及与体重异常的交互作用  

Roles of peroxisome proliferator-activated receptors polymorphisms, haplotypes, levels on C-reactive protein and their interactions with abnormal body weight

作　　者：俞璐刚 周正元[2] 郭志荣[3] 武鸣[4] 顾淑君[3] 

机构地区：[1]苏州工业园区疾病防治中心,215021 [2]江苏省常熟市疾病预防控制中心 [3]苏州大学公共卫生学院流行病与卫生统计学教研室 [4]江苏省疾病预防控制中心慢病科

出　　处：《中华流行病学杂志》2013年第10期1023-1029,共7页Chinese Journal of Epidemiology

基　　金：卫生部科学研究基金（WKJ2004-2-014）

摘　　要：目的探讨过氧化物酶体增殖物激活受体（PPAR）α／δ／γ多态性及单体型与C反应蛋白（CRP）的关联，并分析单体型和体重异常的交互作用对CRP的影响。方法在“江苏省多代谢异常和代谢综合征综合防治研究队列人群”的基础上，采用单纯随机抽样方法，选取644名研究对象。应用方差和t检验，以线性回归模型分析单核苷酸多态性（SNP）基因型与CRP水平的关联。采用SNPStats软件对PPAR个亚型SNP分别构建单体型，并分析单体型与体重异常的交互作用对CRP水平的影响。结果调整性别、年龄、血压、吸烟和饮酒等因素后，rs1800206和rs9794与CRP水平有显著关联（P〈0．05）。调整相同因素后，PPARα中AVG和CVG两个单体型、PPARδ中CG单体型与CRP水平升高有关（P〈0．05）；PPARδ中CC单体型、PPARy中CPCAC单体型与CRP水平降低有关（P〈0．05）。调整相同因素后，PPARα的AVG和CVG单体型与体重异常对CRP水平有交互作用（P〈0．05）。PPARδ中，CG单体型与体重异常对CRP水平有交互作用（P〈0．05）。结论PPAR多个SNP及其单体型与CRP有显著关联；PPARα／δ单体型与体重异常存在交互作用并对CRP水平产生影响。Objective To explore the roles of peroxisome proliferator-activated receptors （PPARs） on the levels of serum C-reactive protein （CRP） and the interactions of PPARs haplotypes with abnormal body weight. Methods Subjects （n=644） were randomly selected from the cohort ＇Prevention of Multiple metabolic disorders and Metabolic syndrome in Jiangsu province （PMMJS） ＇. Variance test, t test and lineal regression were used to analyze the associations between PPARs polymorphisms and the levels of CRP. The association between PPARs haplotypes and serum CRP levels as well as the interaction of PPARs haplotypes with abnormal body weight were analyzed, under the SNPStats software. Results After adjusting for sex, age, blood pressure, cigarette smoking, alcohol drinking and so on, data showed that both rs1800206 and rs9794 were associated with the changes along with the levels of CRP （P〈0.05）. After adjusting for the same factors, haplotypes of AVG and CVG in PPARα, CG in PPARδ appeared to be associated with the increase （P〈0.05） while haplotypes of CC in PPARδ, CPCAC in PPARγ were associated with the decrease of CRP levels （P〈0.05 ）. Results from the Interaction analysis also noted that the interactions did exist between abnormal body weight and both AVG, CVG in PPARa, and CG in PPARδ. Conclusion PPARs polymorphisms and haplotypes were associated with CRP. Interaction between PPAR α/δ and abnormal body weight might contribute to the levels of CRP.

关 键 词：体重异常 过氧化物酶体增殖物激活受体 C反应蛋白 交互作用 

分 类 号：R446.6[医药卫生—诊断学]