维生素B12水平对不良妊娠结局的相关性探讨  

Investigation of the relationship between birth defects and unexplained recurrent pregnancy loss and vitamin B12

作　　者：李敏[1] 王华[1] 谢晓媛[1] 马佳梅[1] 程静[1] 

机构地区：[1]天津市妇女儿童保健中心检验科,天津300070

出　　处：《中国城乡企业卫生》2013年第5期117-118,共2页Chinese Journal of Urban and Rural Enterprise Hygiene

摘　　要：目的探讨血浆叶酸、红细胞叶酸和维生素B12水平与不良妊娠结局的关系。方法选择具有不良妊娠结局的育龄非孕妇女54例为观察组,正常非孕妇女63例为对照组,检测两组血浆叶酸、红细胞叶酸及维生素B12水平。结果 (1)两组血浆叶酸及红细胞叶酸比较差异无统计学意义,观察组维生素B12显著降低;(2)对照组血浆叶酸和红细胞叶酸均正常,维生素B12<256pg/ml1例;观察组血浆叶酸<4.63ug/L1例,红细胞叶酸<160.8ug/L1例,维生素B12<256pg/ml7例,缺乏率为13%。结论维生素B12缺乏可能与出生缺陷及复发性流产相关,早期预防性口服叶酸和维生素B12,可能会减少出生缺陷及复发性流产的发生。Objective To study the relationship between birth defects and unexplained recurrent pregnancy loss and folic acid, red blood cell folio and vitamin B12. Methods 54 non-pregnant women at child-bearing age with a birth defect history were selected as birth defect group. 63 normal women were selected as control group. We determined the levels of folio acid, red blood cell folic and vitamin B12. Results （ 1 ）There were no significant difference of folio acid and red blood cell folic levels between birth defect group and control group. The level of vitamin B12 in birth defect group was significantly lower. （2）The levels of folic acid and red blood cell folic in Control group were in the normal range and there was one case lack of vitamin B12. There were one case of birth defect group lack of folio acid and red blood cell folio, respectively. The vitamin B12 deficiency rate in birth defect group was 13%. Conclusion The lack of vitamin B12 may be related to the occurrence of birth defects and unexplained recurrent pregnancy loss. Add vitamin B 12 should be adopted to maintain normal levels of vitamin B 12,which will benefit the maternal and child health.

关 键 词：血浆叶酸 红细胞叶酸 维生素B12 畸形 出生缺陷 流产 

分 类 号：R591.424[医药卫生—内科学]