病毒相关性喘息患儿血清中嗜酸性粒细胞及其趋化因子的检测及临床意义  

The detection and clinical significance of eosinophil and eotaxin in the children with virus associated wheezing diseases

作　　者：范秋霞[1] 张爱荣[2] 

机构地区：[1]河南省商丘市第一人民医院儿二科,476100 [2]河南省商丘市第一人民医院检验科,476100

出　　处：《中国医师进修杂志》2013年第27期5-7,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的检测病毒相关性喘息患儿血清中嗜酸性粒细胞及其趋化因子的水平，探讨二者在病毒相关性喘息发生、发展中的作用。方法选择68例病毒相关性喘息患儿作为观察组，另选择42例健康儿童作为对照组，检测并比较观察组急性期和恢复期及对照组儿童外周血嗜酸性粒细胞计数和血清嗜酸性粒细胞趋化因子水平。结果观察组急性期嗜酸性粒细胞计数为（1．12±0．62）×10^9／L，恢复期为（0．34±0．13）×10^9／L，对照组为（0．16±0．07）×10^9／L，观察组急性期嗜酸性粒细胞计数高于恢复期和对照组，且观察组恢复期高于对照组，差异均有统计学意义（P〈0．05）。观察组急性期嗜酸性粒细胞趋化因子水平为（437．2±87．6）ng／L，恢复期为（182．4-t-56．2）n玑，对照组为（84．1±39．7）n尚也，观察组急性期嗜酸性粒细胞趋化因子水平高于恢复期和对照组，且观察组恢复期高于对照组，差异均有统计学意义（P〈0．05）。观察组急性期、恢复期以及对照组血清嗜酸性粒细胞趋化因子水平与其外周血嗜酸性粒细胞计数呈正相关（r=0．579、0．593、0．581，P〈0．05）。结论嗜酸性粒细胞及其趋化因子可能参与了病毒相关性喘息患儿的病理生理过程，二者水平的测定可监测婴幼儿喘息的病程变化，有利于临床诊治。Objective To detect the levels of eosinophil and eotaxin in the children with virus associated wheezing diseases, and explore the role of both in virus correlation breathing occurrence and development. Methods Sixty-eight cases of children with virus associated wheezing diseases were selected as observation group, and the other 42 cases of healthy children were selected as control group. The peripheral eosinophil count and serum eotaxin level were detected and compared in observation group and control group on the acute stage and recovery stage. Results The eosinophil count in observation group on the acute stage was （ 1.12 ± 0.62） x 10^9/L, the recovery stage was （0.34 ±0.13 ） x 10^9/L, control group was （0.16 ± 0.07 ） x 10^9/L,the eosinophil count in observation group on the acute stage was higher than that on the recovery stage and control group, the eosinophil count in observation group on the recovery stage was higher than that in control group, there were statistically significant differences （P 〈 0.05）. The eotaxin level in observation group on the acute stage was （437.2 ±87.6） ng/L, the recovery stage was （182.4 ±56.2） ng/L, control group was （ 84.1 ± 39.7 ） ng/L, the eotaxin level in observation group on the acute stage was higher than that on the recovery stage and control group, the eotaxin level in observation group on the recovery stage was higher than that in control group,there were statistically significant differences （P 〈 0.05）. There were positively correlated between the eosinophil count and the eotaxin level in observation group on the acute stage, recovery stage and control group （r = 0.579, 0.593, 0.581, P 〈 0.05 ）. Conclusions The eosinophils and eotaxin may be involved in the children with virus associated wheezing diseases pathophysiological process, the levels of the eosinophils and eotaxin can monitor the course change, and be helpful for clinical diagnosis and treatment.

关 键 词：儿科学 粒细胞 哮喘 病毒 

分 类 号：R725.6[医药卫生—儿科]