检测脐血中的麻疹抗体滴度对评估人群整体麻疹抗体水平的价值研究  

The value of detection of measles antibody in cord blood for estimation of the crowd measles antibody level

作　　者：孙宝霞[1] 孙秀侠[2] 周原[3] 王延田[4] 

机构地区：[1]山东省枣庄市立医院感染疾病科,277101 [2]山东省枣庄市立医院公共卫生科,277101 [3]山东省枣庄市立医院妇产科,277101 [4]山东省枣庄市疾病预防控制中心麻疹实验室

出　　处：《中国医师进修杂志》2013年第27期10-11,共2页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨脐血胎传麻疹抗体滴度与母体麻疹抗体滴度的相关性，以此评估人群整体麻疹抗体水平，为持久消除麻疹提供科学依据。方法采集40对健康产妇静脉血和配对脐血，分别采用酶联免疫吸附法检测麻疹抗体滴度。结果在1：200滴度水平母血与脐血麻疹抗体滴度分别为11．29±4．81和12．76±5．32，在1：800滴度水平分别为6．89±4．11和8．28±4．91，两者均有相关性（r=0．575、0．618，P〈0．05）。结论产妇静脉血与配对脐血的麻疹抗体滴度呈高度相关性，表明母体麻疹抗体通过胎盘传给子体，脐血中检测到的麻疹抗体滴度，既可以作为评估母体麻疹抗体水平的指标，也可以作为预测新生儿、低龄儿麻疹抗体水平的指标。Objective To investigate the correlation between umbilical cord blood tire mass measles antibody and maternal measles antibody degrees, in order to evaluate the crowd measles antibody level and provide scientific basis for lasting elimination of measles. Methods Collected 40 cases of heahhy maternal venous blood and their paired cord blood, enzyme-linked immunosorbent assay （ELISA） was used for the detection of measles antibody. Results In the 1 ： 200 level,mother blood and umbilical cord blood of measles antibody level were 11.29 ＋4.81 and 12.76 ~5.32,in the 1 ： 800 level were 6.89 ＋4.11 and 8.28 ＋4.91,both had correlation （r =0.575,0.618,P 〈0.05）. Conclusions Measles antibody titers of maternal venous blood and paired cord blood are highly correlated. The results show that maternal measles antibodies could pass through the placenta to the daughter, and measles antibody titers detected in umbilical cord blood can be used not only to assess the maternal measles antibodies level, but also can be used as a predictor of measles antibody levels for newborns and young children.

关 键 词：麻诊病毒 胎血 抗体 

分 类 号：R446.6[医药卫生—诊断学]