鸡支康口服液的亚慢性毒性试验研究  

Study on Subchronic Toxicity Test of Jizhikang Oral Liquid

作　　者：洪伟鸣[1] 左伟勇[1] 宋亮[1] 黄文强[1] 郁杰[1] 

机构地区：[1]江苏畜牧兽医职业技术学院,江苏省兽用生物制药高技术研究重点实验室,江苏泰州225300

出　　处：《中国畜牧兽医》2013年第9期140-143,共4页China Animal Husbandry & Veterinary Medicine

基　　金：江苏牧院2012年院级课题(QN1204)

摘　　要：试验根据《兽药试验技术规范汇编》进行了鸡支康口服液对小白鼠的亚慢性毒性研究,试验设高、中、低3个剂量组,另设空白对照组,连续给药28 d后剖杀各组小鼠,观察其临床表现,并进行血常规和血液生化指标检测及脏器系数和组织病毒学检查。统计学分析结果表明,各组间的体重变化和脏器系数均无显著差异(P>0.05);血常规检查结果表明,试验组的红细胞数、血小板数、红细胞压积及淋巴细胞数与空白对照组相比呈下降趋势,但差异不显著(P>0.05),其余各检测指标各试验组与空白对照组相比差异均不显著(P>0.05);血液生化指标结果表明,试验组的谷丙转氨酶、谷草转氨酶及血糖含量与空白对照组相比呈下降趋势,但差异不显著(P>0.05),其余各检测指标各试验组与空白对照组相比差异均不显著(P>0.05);组织病理学检查结果显示,小鼠的主要内脏器官未见明显异常。试验结果表明,鸡支康口服液对小鼠血常规和血液生化指标影响甚微。提示,其按临床剂量使用无毒性反应,安全可靠。In order to study the subchronic toxicity of the Jizhikang oral liquid, the test was conducted in accordance with the animal drug technological specification compile of Ministry of Agriculture. Experiment mice were divided into 4 groups, the 3 experiment groups were given Jizhikang oral liquid of 0.01,0.02,0.04 mL/（g·BW） for 28 days. The control group was given the same amount of naomal saline. The results showed that the body weight, organ coefficient, index of hematology and blood biochemistry indices in 3 experiment groups were not significantly different from that in the control group（P〉0.05）. Results of histopathology examination showed that it had no adverse reaction in experiment groups. The results showed that the Jizhikang oral liquid had no subchronic toxicity,and could be safely used for experimental animals.

关 键 词：鸡支康口服液 小鼠 亚慢性毒性试验 

分 类 号：S592.1[农业科学—作物学]