干细胞培养微流控芯片气室的分析与设计  

Analysis and Design on Air Chamber of Microfluidic Chip for Culturing Stem Cells

作　　者：王桐[1] 陈涛[1] 左铁钏[1] 

机构地区：[1]北京工业大学激光工程研究院,北京100124

出　　处：《北京工业大学学报》2013年第10期1459-1463,共5页Journal of Beijing University of Technology

基　　金：国家自然科学基金资助项目(50875007);国家重大科学仪器专项项目子课题(2011YQ030112)

摘　　要：利用Realizableκ-ε有限元模型,对17种气室结构进行了流体力学分析.通过对比分析,按照迅速换气并减少气体残留的要求,以减少气体流速较小部分所占气室体积的比例为优化条件,从17种结构中筛选出2种适合为干细胞培养提供气体的结构;总结出2条设计规律;在实际设计中对这一结构进行了适当改进,以进一步减少气体残留.仿真结果表明,本文筛选并改进的结构适用于干细胞培养微流控芯片.Based on fluid dynamics, 17 types of air chambers are studied using finite element method and Realizable k-ε model in this paper. By comparing analysis results, two are selected from 17 types of air chambers according to changing air quickly and remaining less old air, which are fitful for providing air for stem cells on microfluidic chip. Two experiences are obtained from the analysis. In practical terms, appropriate improvement is made for remaining less old air further. Results show that the chosen and improved chamber is suitable for using microfluidic chip to culture stem cells.

关 键 词：干细胞 微流控 生物芯片 有限元法 

分 类 号：Q813[生物学—生物工程] TH79[机械工程—仪器科学与技术]