布洛芬联合芎麻汤对利血平化低5-HT伴局部脑血管痉挛的偏头痛模型的影响  

Role of Ibuprofen Joint Xiongma Decoction in Migraine Model of Low 5-HT with Local Cerebral Vasospasm by Reserpine

作　　者：徐成坤[1] 郭建生[2] 

机构地区：[1]南华大学附属第一医院,湖南衡阳421001 [2]湖南中医药大学,长沙410208

出　　处：《中国现代应用药学》2013年第9期940-943,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：湖南省高校创新平台开发基金项目(11K048);湖南省研究生科研创新项目(CX2010B351)

摘　　要：目的研究布洛芬联合芎麻汤对利血平化低5-HT伴局部脑血管痉挛的实验性偏头痛模型小鼠的作用。方法采用皮下注射利血平10 mg·kg-114d建立偏头痛模型,第14天小鼠乙醚麻醉,经颅穿刺大脑皮层注射自身鼠血凝块2μL·只-1,观察布洛芬联合芎麻汤对利血平偏头痛小鼠体质量、凝血时间及血清中5-HT及其代谢产物5-HIAA含量的影响。结果布洛芬联合芎麻汤能增加偏头痛小鼠的体质量,延长凝血时间,调节5-HT的过度降低,提高血清中5-HIAA的含量,与模型组比较,差异具有统计学意义(P<0.01)。结论布洛芬联合芎麻汤对于利血平所致小鼠偏头痛具良好疗效。OBJECTIVE To study the role of ibuprofen joint Xiongma decoction in the migraine model mice of low 5-HT with local cerebral vasospasm induced by reserpine. METHODS By giving hypodermic injection of 10 mg-kg-1 reserpine for 14 days, copied migraine model was established. On the 14th day after ether anesthesia in mice, puncture cerebral cortex to inject blood clots（2μL per mice） was conducted, to observe the effect of ibuprofen joint Xiongma decoction on weight, coagulation time, 5-HT and 5-HIAA level in plasma. RESULTS Ibuprofen joint Xiongma decoction could increase body weight, prolong coagulation time, prevent excessive decrease in 5-HT and improve the content of 5-HIAA. Compared with the model group, the difference was significant（P〈0.01）. CONCLUSION Ibuprofen joint Xiongma decoction is effective on migraine mice induced by reserpine.

关 键 词：布洛芬 芎麻汤 偏头痛 

分 类 号：R969.4[医药卫生—药理学]