北京市新生儿脐带血风疹抗体水平调查  

Survey on rubella antibody level in neonatal cord blood in Beijing

作　　者：王庆[1] 孙木[1] 王兆华[1] 张晶波[1] 崔京辉[1] 严荔煌[2] 刘捷[2] 

机构地区：[1]北京市西城区疾病预防控制中心,北京100120 [2]北京大学人民医院

出　　处：《现代预防医学》2013年第19期3594-3596,共3页Modern Preventive Medicine

摘　　要：目的了解北京市新生儿风疹病毒宫内感染情况,评估育龄妇女风疹抗体水平,为预防先天性风疹综合症(CRS)提供科学依据。方法随机选取在北京大学人民医院产科分娩的孕产妇及其新生儿1 000对,采用酶联免疫吸附试验开展脐带血风疹IgM、IgG抗体检测。结果监测的新生儿中,有1例风疹IgM抗体阳性。孕产妇(育龄妇女)风疹IgG抗体阳性率为84.20%,几何平均浓度(GMC)为54.10 IU/ml。各年龄组之间抗体阳性率和GMC有显著性差异,随着年龄的增长,抗体阳性率和GMC呈下降趋势。结论当有风疹暴发流行迹象时,应适时开展对育龄期妇女的风疹疫苗接种工作,预防CRS的发生。OBJECTIVE To know the intrauterine rubella virus infection and the immune level of rubella in women of childbearing age in Beijing, and to provide scientific basis for preventing congenital rubella syndrome （CRS）. METHODS 1 000 pairs of pregnant women and their newborns were randomly selected in the People＇ s Hospital of Peking University. A quantita- tive enzyme-linked immunosorbent assay （ELISA） was used to test the level of rubella IgM and IgG antibodies in cord blood. RESULTS In 1 000 newborns, one case of rubella IgM antibody positive was found. The positive rate of rubella IgG antibody in women of childbearing age was 84.20%, and the geometric mean concentration （GMC） was 54.10 IU/ml. The differences of the positive rate and GMC between different age groups were statistically significant. With age increasing, the positive rate and GMC decreased. CONCLUSION When rubella outbreaks, the immunization should be strengthened for the women of childbearing age to prevent CRS.

关 键 词：宫内感染 育龄妇女 风疹抗体 先天性风疹综合征 

分 类 号：R511.2[医药卫生—内科学]