大黄酸、大黄素和大黄酚体外抗阴道毛滴虫作用的观察  

Observation on effect of rhein, emodin and chrysophanol on anti trichomonas vaginalis in vitro

作　　者：孙宝清[1] 张丽娟[1] 谭桂莲[1] 董会霞[1] 魏秋芬[1] 

机构地区：[1]首都医科大学燕京医学院,北京101300

出　　处：《现代预防医学》2013年第19期3654-3656,共3页Modern Preventive Medicine

基　　金：北京市教育委员会科技发展计划面上项目(KM200910025014)

摘　　要：目的观察大黄酸、大黄素和大黄酚体外抗阴道毛滴虫的效果。方法采用显微镜计数法,观察大黄酸、大黄素和大黄酚在不同浓度、不同作用时间对体外阴道毛滴虫的作用。结果大黄酸、大黄素和大黄酚在不同浓度、不同作用时间的杀虫效果比较差异均有统计学意义(P﹤0.005),3种药物之间各浓度的杀虫效果比较差异均无统计学意义(P﹥0.005)。结论大黄酸、大黄素和大黄酚在体外均有抗阴道毛滴虫的作用。随着药物浓度的增加和药物作用时间的延长,阴道毛滴虫死亡率增高。OBJECTIVE To observe anti-traichomonas vaginalis effect：with rhein, emodin and chrysophanol in vitro. METHODS Adopted the microscope count method to observe the anti-trichomonas vaginalis ability of rhein, emodin and chrysophanol in different concentration rates and different treatment time. RESULTS The resuhs of killing trichomonas vagi- nalis with rhein, emodin and chrysophanol in different time had statistical significances （P 〈 0.005）, while no statistical significance in different concentration rates （P 〉 0.05）. CONCLUSION Rhein, emodin and chrysophanol all have the ability to kill tfiehomonas virginals in vitro. As the treatment time prolong, the mortality rate of trichomonas vaginalis increases.

关 键 词：阴道毛滴虫 大黄酸 大黄素 大黄酚 作用 

分 类 号：R382.21[医药卫生—医学寄生虫学]