黄芪多糖对顺铂治疗S180荷瘤鼠的增效减毒作用  

Synergism and attenuation effect of Astragalus Polysaccharide on cisplatin in the treatment of mice bearing S180 tumor

作　　者：孙舒玉[1] 何小鹃[2] 罗丹[3] 吕诚[2] 荆生龙[2] 吕爱平[2] 喻长远[1] 

机构地区：[1]北京化工大学生命科学与技术学院,北京100029 [2]中国中医科学院中医临床基础医学研究所,北京100700 [3]北京中医药大学,北京100029

出　　处：《中国中医基础医学杂志》2013年第9期787-789,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金资助项目(81001676;81273631)

摘　　要：目的:探讨黄芪多糖对顺铂治疗S180荷瘤鼠的增效减毒作用。方法:建立S180荷瘤小鼠模型,BALB/c小鼠随机分为正常组、模型组、顺铂(DDP)组、黄低组、黄低+DDP组、黄高组和黄高+DDP组。造模后第2天开始给药,14d后处死各组小鼠,取血清测谷丙转氨酶含量,取肝脏称重计算肝脏指数,取肿瘤称重计算抑瘤率。结果:黄芪多糖能够抑制荷瘤鼠肿瘤的生长(P<0.05),与顺铂联合使用具有协同作用(P<0.01)。与DDP组比较,给药第14天时联合用药组荷瘤鼠的体质量明显增加(P<0.05)。与DDP组比较,联合用药后黄芪多糖可使荷瘤鼠肝脏指数升高(P<0.05),谷丙转氨酶含量降低(P<0.05)。结论:黄芪多糖对顺铂治疗荷瘤小鼠有增效减毒作用。Objective： To investigate the effects of Astragalus polysaccharide （APS） to diamminedichloroplatinum （DDP） treatment on tumor-bearing mice. Method： Mice were subcutaneously implanted with S180 cells in the right axillary region. Then these mice were randomly divided into model group, DDP group, APS low dose group, APS low dose plus DDP group, APS high dose group, and APS high dose plus DDP group. Another ten normal mice were used as normal control. After 24 h, intragastric administration was begun. After fourteen day~ of intragastric administration, liver and tumors were taken out and weighed. Result： The results showed that APS could inhibit the S180 tumor growth（P 〈 0. 05） , the combinations of APS and DDP had the effect of synergies （P 〈 O. 01 ）. On the fourteen day, compared with DDP group, the weights of mice in the combination group was higher（P 〈 0. 05 ）. Compared with DDP group, the toxicity of liver in the combination group was lower（P 〈 0. 05 ）. Conclusion ： The results indicated that combined application of APS and DDP had the effects of attenuated synergies.

关 键 词：黄芪多糖 顺铂 肿瘤 增效减毒 

分 类 号：R285.5[医药卫生—中药学]