复方黄芪附子汤对维持性血液透析患者红细胞CD58与CD59的影响  

Effect of Huangqifuzitang on immune function of red blood cell CD58 and CD59 in patients with hemodialysis

作　　者：朱梦华[1] 汤英玲[1] 李旭[2] 邹明[2] 于铁[3] 高弼虎[1] 

机构地区：[1]大连大学附属中山医院肾内科,116001 [2]大连大学附属中山医院药剂科,116001 [3]大连大学附属中山医院中医科,116001

出　　处：《中国综合临床》2013年第10期1043-1046,共4页Clinical Medicine of China

摘　　要：目的红细胞免疫低下是尿毒症维持性血液透析患者并发肿瘤的主要原因之一，而氧化应激是严重影响尿毒症维持性血液透析患者生存质量及引发各种并发症的主要原因。通过探讨血液透析患者红细胞免疫低下及高氧化应激状态的特点，观察中药“复方黄芪附子汤”（芪附汤）对患者红细胞CD58、CD59及氧化应激指标的调节作用。方法检测维持性血液透析患者应用“芪附汤”前（用药前组）、后（用药后组）CD58、CD59、超氧化物歧化酶（SOD）、丙二醛（MDA）的浓度，并与同期大连大学附属中山医院体检中心的健康人20名（对照组）的上述指标进行对比。结果用药前、服用“芪附汤”12d后及对照组CD58[（38．02±8．98）、（47．39±7．78）％与（59．10±4．59）％；F=4．506，P=0．000]、CD59[（62．69±20．84）、（80．95±20．42）％与（193．864-19．87）％；F=239．347，P=0．000]、SOD[（68．09±11．86）、（78．73±10．58）、（111．09±16．61）kU／L；F=21．318，P=0．000]、MDA[（5．98±2．06）、（4．54±O．62）、（3．03±1．10）μmol／L；F=55．359，P=0．000]比较，差异均有统计学意义；用药前CD58、CD59、SOD浓度较对照组明显降低，MDA明显升高，差异均有统计学意义（P均〈0．01）；服用“复方黄芪附子汤”12d后，CD58、CD59、SOD较用药前明显升高，MDA较用药前明显降低，差异均有统计学意义（P〈0．01或P〈0．05）。结论血液透析患者红细胞表面受体CD58、CD59表达力降低，氧化应激指标SOD明显降低，MDA明显增高，“复方黄芪附子汤”能显著提高维持性血液透析患者的红细胞CD58、CD59浓度，改善患者的氧化应激状态。Objective The immune hypofunction of the red blood cell on maintenance hemodialysis patients is one main reason of tumor, and oxidative stress is proved to be involved in decrease of existence quality and the occurrence of various complications of patients with hemodialysis. To investigate the status of erythrocyte immune and high oxidative stress of the hemodialysis patients, as well as the effect of Huangqifuzitang on immune function of red blood cell and oxidative stress in patients with hemodialysis. Methods Twenty healthy people were chosen as control group, and 20 patients were selected as the treatment group. CD58, CD59, superoxide dismutase（ SOD）, malonaldehyde（MDA） were measured before hemodialysis and after 12 days administration of Huangqifuzitang in the treatment group, and compared with those of the control group. Results There was significant difference between before and after taking Huangqifuzitang in treatment group and control group in terms of CD58（（38.02 ±8.98） vs. （47.39 ±7.78） vs. （59.10 ±4.59）,F=4.506,P=0.000）,CD59 （ （62. 69 ±20. 84） vs. （ 80. 95 ±20. 42 ） vs, （ 193.86±19. 87 ） ; F = 239. 347, P = 0. 000）, SOD （ （ 68.09 ± 11.86） vs. （78.73±10.58） vs, （111.09±16.61） kU/L;F=21.318,P=O. OOO）,MDA（（5.98±2.06） vs. （4. 54 ±0. 62） vs. （3.03 ± 1.10）μmol/L;F =55. 359,P =0. 000） levels. Before taking Huangqifuzitang, the concentration of CD58, CD59 and SOD in treatment group was significant decreased compared with control group, but MDA significant increased, and there was significant difference （ P 〈 0. 01 ） . After 12 days administration of Huangqifuzitang in the treatment group, the concentration of CD58, CD59 and SOD was significant increased compared with before ＇taking Huangqifuzitang, but MDA significant significant decreased, and there was significant difference （P 〈 0. 01 or P 〈 0.05 ） Conclusion The red blood cell surface receptors CD58, CD59 decreased and oxidative stress index SOD decreased

关 键 词：尿毒症 血液透析 红细胞免疫 氧化应激 复方黄芪附子汤 

分 类 号：R277.5[医药卫生—中医学]