羟氯喹治疗慢性光化性皮炎发生银屑病样皮损  

Psoriasis-like lesions developed after treatment of chronic actinic dermatitis with hydroxychloroquine

作　　者：吴成[1,2] 胡华英 周晓鸿[1] 张佩莲[1] 邓丹琪[1] 

机构地区：[1]昆明医科大学第二附属医院皮肤科,云南昆明650000 [2]随州市中心医院皮肤科,湖北随州441300 [3]文山州丘北县人民医院皮肤科,云南文山663200

出　　处：《临床皮肤科杂志》2013年第10期592-594,共3页Journal of Clinical Dermatology

摘　　要：报告1例慢性光化性皮炎患者羟氯喹治疗后发生银屑病样皮损。患者男,63岁。面部、颈部、双手背、胸部V形区反复弥漫浸润性红斑丘疹10余年。2011年12月开始口服羟氯喹,2个月后躯干、四肢出现银屑病样皮损,结合皮损组织病理结果诊断为:慢性光化性皮炎和银屑病样皮损(药疹?寻常性银屑病?),停用羟氯喹2个月后躯干、四肢皮损消退,半年后无复发,银屑病样皮损考虑为服用羟氯喹诱发。A 63-year-old male presented with diffuse infiltrated erythema, papules on the face, neck, dorsal hands and V- shaped area of the chest for 10 years. He took oral hydroxychloroquine sulfate tablets in December 2011. Two months later psoriasis-like lesions appeared on his trunk and limbs. Combined with histopathological findings and clinical features, chronic actinic dermatitis and psoriasis-like lesions （drug eruption？ psoriasis vulgaris？） were diagnosed. Lesions on his trunk and limbs disappeared 2 months after stopping oral hydroxyehloroquine sulfate. No lesion recurred after six months. Psoriasis-like lesions are thought to be induced by oral hydroxychloroquine sulfate. The patient is still under follow up.

关 键 词：慢性光化性皮炎 羟氯喹 银屑病样皮损 

分 类 号：R758.1[医药卫生—皮肤病学与性病学]