脓毒症患儿低钙血症与炎性指标及白蛋白的相关性分析  

Correlation Analysis on Hypocalcemia with Inflammatory Indices and Albumin in Children with Sepsis

作　　者：陈芬[1] 姚彤[1] 罗新辉[1] 

机构地区：[1]新疆维吾尔自治区人民医院儿科,新疆乌鲁木齐830001

出　　处：《新疆医学》2013年第7期14-17,共4页Xinjiang Medical Journal

摘　　要：目的:探讨脓毒症患儿低钙血症与炎症指标及白蛋白的相关性。方法:收集2011年1月～2012年10月确诊为脓毒症患儿74例,依据病情轻重分为普通脓毒症组(50例)及严重脓毒症组(20例),检测脓毒症患儿急性期及恢复期的血钙水平并进行比较。根据急性期血钙水平将74例脓毒症患儿分为血钙正常组及低血钙组,比较两组WBC、CRP及白蛋白,并对3个指标与血钙水平进行相关性分析。结果:严重脓毒症组急性期血钙水平明显低于普通脓毒症组(P<0.05),恢复期两组血钙水平无统计学意义。两组脓毒症组急性期与恢复期的血钙水平相比较有统计学意义(P<0.05)。74例脓毒症患儿中,低血钙组WBC、CRP均高于血钙正常组(均P<0.05),而低钙血症组白蛋白水平明显低于正常血钙组(P<0.05)。低钙血症组器官功能受累的发生率较血钙正常组增高(P<0.05),且血清钙离子水平与WBC、CRP呈负相关,与白蛋白水平呈正相关。结论:脓毒症患儿血钙水平明显降低,且随病情的加重而进一步降低,血钙水平越低,预后越差。反应脓毒症的炎症指标WBC、CRP与血清钙离子水平呈负相关,与白蛋白水平呈正相关。Objective ：To investigate the correlation of hypocalcemia with inflammatory indices and albumin in children with sepsis. Methods Seventy- four children with sepsis were enrolled. On the basis of the severity of the disease is divided into ordinary sepsis group（54 case） and severe sepsis group（ 20 case）. Detection of sepsis in chil- dren with acute and convalescent serum calcium levels and compared them. Based on the level of acute calcium lev- els, 74 cases of sepsis were classified into two groups： hypocalcemia and normal calcium. WBC, Blood CRP and al- bumin levels were compared in the two groups. The correlation of WBC, CRP and albumin with calcium level was evaluated. Results calcium levels of acute in the severe sepsis groups were significantly lower than those in the non- severe sepsis group （P〈0.05）, but the two groups were i,o statistically significant difference in convalescent serum calcium levels. Two sets of sepsis of acute and convalesccnt set＇urn calcium levels were compared statistically differ- ence （P〈0.05）.WBC levels and Blood CRP in the hypoe：lleenfia gt＇oup were higher than those in the normal calcium group （P〈O.05）, but senml albumin levels in the hypocalcemia group were lower than those in the normal calcium group（P〈0.05）. The incidence of muhiple organ failure in Hypocalcemia group was significantly higher than that in the nomml calcium group（P〈0.05）. Senlln calcium levels were negatively correlated with WBC and blood CRP, and were positively correlated with albumin levels. Conclusions Serumcalcium levels decrease in children with sepsis, and the more serious the illness, the lower serum albumin levels, resulting in a worse prognosis. WBC and CRP are negatively correlated to serum calcium levels in children with sepsis, and albumin levels were positively correlated.

关 键 词：脓毒症 低钙血症 C-反应蛋白 白蛋白 儿童 

分 类 号：R392[医药卫生—免疫学]