糖尿病人群健康行为和健康因素与高敏C反应蛋白水平的相关性研究  

Correlations of health behaviors and factors with high sensitivity C-reactive protein in diabetic population

作　　者：侯金泓[1] 王剑利[1] 陈朔华[1] 刘艳[1] 刘静[1] 吴寿岭[1] 

机构地区：[1]开滦总医院肾内科,河北唐山063000

出　　处：《解放军医学杂志》2013年第10期842-846,共5页Medical Journal of Chinese People's Liberation Army

摘　　要：目的探讨理想心血管健康行为和健康因素与糖尿病人群hsCRP水平的相关性。方法采用横断面研究方法,以开滦集团公司2006-2007年度健康体检职工中的糖尿病人群为研究对象(n=7869),进行统一问卷调查和血液生化检查,采用多因素logistic回归分析理想心血管健康行为和健康因素对hsCRP水平的影响。结果随着健康行为和健康因素数量的增多,hsCRP水平逐渐降低,具有0-1项、2项、3项、4-6项理想心血管健康行为和健康因素的人群,其hsCRP中位数依次为1.16、1.11、0.90、0.76mg/L(P<0.01)。多因素logistic回归分析表明,在校正性别、年龄、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)等危险因素后,具有3项、4-6项理想心血管健康行为和健康因素的人群hsCRP超过3mg/L的风险分别是具有0-1项健康行为和健康因素人群的0.60、0.45倍。结论理想的健康行为和健康因素数量越多,hsCRP超过3mg/L的风险越低。Objective To explore the correlations of ideal cardiovascular health behaviors and factors with the level of high sensitivity C-reactive protein （hsCRP） in diabetic population. Methods A cross-sectional method was used in present study. Seven thousand eight hundred and sixty-nine workers with diabetes were recruited who participated in the 2006-2007 Kailuan health examination without history of cerebral and myocardial infarction and without data incompleted. All the information was obtained from the unified questionnaire and measurement of blood biochemistry. Multivariate logistic regression analysis was used to analyze the effects of ideal cardiovascular health behaviors and factors on the level of hsCRP. Results The hsCRP concentrations decreased with the increasing numbers of ideal cardiovascular health behaviors and factors, the medians of hsCRP concentrations were 1.16mg/ L, 1.11mg/L, 0.90mg/L and 0.76mg/L in 0-1, 2, 3 and 4-6 ideal cardiovascular health groups, respectively （P〈0.01）. Multivariate logistic regression analysis showed that, after adjustment by age, gender, triglyceride, low density lipoprotein cholesterol （LDL-C） and high density lipoprotein cholesterol （HDL-C）, the risk of hsCRP level exceeding 3mg/L in the subjects having 3 and 4-6 ideal cardiovascular health behaviors and factors was 0.60 times （95%CI 0.50-0.72） and 0.45 times （95%CI 0.34-0.61）, respectively, than those having 0-1 ideal cardiovascular health behaviors and factors. Conclusion The hsCRP concentrations decreased with increasing numbers of ideal cardiovascular health behaviors and factors; the risk of hsCRP exceeding 3mg/L can be reduced by ideal cardiovascular health behaviors and factors.

关 键 词：健康行为 健康因素 糖尿病 C反应蛋白 

分 类 号：R587.1[医药卫生—内分泌]