阿卡波糖治疗对2型糖尿病患者血清白细胞介素4、白细胞介素6、白细胞介素10水平的影响  

Effect of acarbose on interleukin-4, -6, and -10 levels in patients with type 2 diabetes mellitus

作　　者：司文[1] 孟秀香[2] 刘奔[3] 刘海霞[1] 赵琳[1] 张霞[1] 张萍[1] 苏本利[1] 

机构地区：[1]大连医科大学附属第二医院内分泌科,116027 [2]大连医科大学检验学院血液学检验教研室 [3]大连医科大学诊断学实验中心

出　　处：《中华内分泌代谢杂志》2013年第9期746-749,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：辽宁省自然科学基金（20062160）

摘　　要：选取4周内未服用阿卡波糖的66例2型糖尿病患者分为阿卡波糖治疗组（A组，34例）及非阿k波糖治疗组（B组，32例），同时选取33名健康志愿者为对照组（c组）。A组给予阿卡波糖150mg/d，B组不服用阿卡波糖．其余治疗与A组相同．疗程4周，酶联免疫吸附法检测治疗前后血清白细胞介素（IL）-4、IL-6、IL-10水平的变化。结果显示，治疗前C组IL-4、IL-10水平明显高于A、B组（P〈0．05），IL-6水平明显低于A、B组（P〈0．05）：经过4周治疗，A、B两组IL-4、IL-10水平均较人组时升高，IL-6水平较人组时降低。但A组IL-4变化趋势与B组无显著性差异，而IL-6、IL-10的变化趋势较B组则更为显著（P〈0．01），提示阿卡波糖干预治疗可显著改善2型糖尿病患者IL水平的异常。Sixty-six patients with type ：2 diabetes mellitus, who did not take acarbose fbr the previous four weeks, were divided into acarbose group （ A group, n = 34 ） and non acarbose group （ B group, n = 32 ）. 33 healthy volunteers were selected as healthy controls （ C group）. Acarbose was prescribed 50 mg three times per day in A group and other hypoglycemic agents apart from acarbose were taken in B group. After four weeks of intervention, interleukin （IL） -4, IL-6, and IL-10 levels were determined with ELISA. The results showed that the baseline levels of IL-4 and IL-10 in C group were significantly higher than those in A and B groups, while the baseline level of IL-6 was lower （ P〈 0.05 ）. After four weeks of intervention, IL-6 level decreased more while IL-10 level increased more in group A than in group B （P〈0.01）. Although IL-4 levels increased in both group A and group B, the trend was not statistically different between two groups. The results suggest that acarbose therapy leads to favorable interleukin profile in patients with type 2 diabetes.

关 键 词：糖尿病 2型 白细胞介素 阿卡波糖 

分 类 号：R587.1[医药卫生—内分泌]