视黄醇结合蛋白4、胱抑素C与2型糖尿病下肢动脉病变的关系  

Relationship of serum retinol binding protein 4 and cystatin C with lower extremity arterial disease in type 2 diabetes mellitus

作　　者：刘姝[1] 李强[1] 刘锴[1] 刘滨菘[1] 韩玉冰[1] 张巾超[1] 

机构地区：[1]哈尔滨医科大学附属第二医院内分泌代谢病科哈尔滨医科大学激素与内分泌疾病重点实验室,150086

出　　处：《中华内分泌代谢杂志》2013年第9期768-771,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：教育部博士学科点基金（200802260007）

摘　　要：选取209例2型糖尿病患者，根据踝肱指数（ABI）分为单纯2型糖尿病组、2型糖尿病伴轻中度闭塞组、2型糖尿病伴重度闭塞组，以60名健康体检者作为对照组。检测血清视黄醇结合蛋白4（RBP4）、胱抑素C和生化指标。结果显示，各组间血清RBP4、胱抑素C水平随下肢动脉病变程度逐渐升高，2型糖尿病伴中度和重度闭塞组显著高于对照组（P〈0．05或P〈0．01），伴下肢动脉病变组RBP4、胱抑素C水平显著高于不伴下肢动脉病变组（均P〈0．01）。Pearson相关分析结果显示总胆同醇、甘油t酯、低密度脂蛋白胆同醇、体重指数、腰臀比、胱抑素C等与血清RBP4呈正相关，与高密度脂蛋白胆固醇呈负相关（P〈0．05或P〈0．01）。Logistic回归分析发现血清RBP4、胱抑素C与2型糖尿病下肢动脉病变显著相关（P〈0．05或P〈0．01）。A total of 209 type 2 diabetic patients were divided into three groups： without, with mild to moderate, or severe diabetic lower extremity arterial disease based on the ankle brachial index value. 60 healthy subjects were used as a control group. Retinol binding protein4 （ RBP4 ） , cystatin C, and biochemical parameters were determined in all subjects. The results showed that RBP4 and cystatin C levels were progressively raised with the increasing severity of lower extremity arterial disease in various groups, being significantly higher in patients with type 2 diabetes mellitus with mild to moderate and severe arterial disease compared with control group （ P〈0.05 or P〈 0.01 ）. RBP4 and cystatin C levels in groups with lower extremity arterial disease were significantly higher than those in the group without arterial disease （ P〈0.01 ）. Pearson correlation analysis showed that RBP4 level was positively correlated with total cholesterol, triglyceride, low density lipoprotein-cholesterol, fasting serum insulin, body mass index, cystatin C etc while negatively correlated with high density lipoprotein-cholesterol （P〈0.05 or P〈0.01 ）. 1,ogistic regression analysis showed that serum RBP4 and cystatin C were significantly associated with lower extremity arterial disease in type 2 diabetes mellitus.

关 键 词：视黄醇结合蛋白4 胱抑素C 糖尿病 2型 动脉粥样硬化 

分 类 号：R587.2[医药卫生—内分泌]