2型糖尿病肥胖患者CXCL5基因多态性的研究  

Study on CXCL5 gene polymorphisms in obese patients with type 2 diabetes mellitus

作　　者：赵艳茹[1] 齐曦明[1] 尹福在[1] 刘波[1] 周钰[1] 刘文[1] 

机构地区：[1]河北医科大学秦皇岛市第一医院,秦皇岛066000

出　　处：《中华内分泌代谢杂志》2013年第9期772-773,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：秦皇岛科学技术研究与发展指导计划项目（201101A271）

摘　　要：探讨CXCL5启动子-156G／C基因多态性与肥胖2型糖尿病的关系。结果显示该基因多态性在2型糖尿病组与对照组的分布差异无统计学意义（P〉0．05），而肥胖者c等位基因频率高于非肥胖者，差异有统计学意义（P〈0．05）。提示趋化因子CXCL5—156G／C基因变异不是糖尿病发病的危险因素，有可能是引起肥胖的重要遗传因素。The association between CXCIA gene polymorphism and obese patmnts with type 2 diabetes mellitus （T2DM） was explored. The distribution of CXCL5 gene promoter region -156G/C poIymort）hism revealed no significant difference between normal eontrol group and T2-DM group （ P〉0.05 ）. The frequency of C allele gene in obesity group was higher than that in non-obesity group（ P〈0.05 ）. The results suggest that the CXCL.5 promoter gene - 156G/C polymorphsim has no relation with T2DM, but it is a risk factor for obesity.

关 键 词：糖尿病 2型 CXCL5 多态性 基因 肥胖症 

分 类 号：R587.1[医药卫生—内分泌]