尼美舒利在全视网膜光凝术中镇痛效果分析  

Assess the effectiveness of nimesulide in reducing pain in panretinal photocoagulation

作　　者：程华[1] 李良平[1] 程显芹[1] 

机构地区：[1]青岛大学医学院附属医院海阳分院眼科,山东海阳265100

出　　处：《中国实用眼科杂志》2013年第9期1135-1138,共4页Chinese Journal of Practical Ophthalmology

摘　　要：目的评估分析尼美舒利在全视网膜光凝术（Panretinal photoeoagulation，PRP）中的镇痛效果。方法应用双盲法进行研究。收集接受PRP治疗的糖尿病视网膜病变患者48例58只眼，随机分为服药组和对照组。在激光治疗前24h开始服用药物2天。激光治疗应用标准化治疗，在治疗结束后应用简式的McGill疼痛问卷表（short form of the McGill pain questionnaire，SF—MPQ）进行评估，内容包括疼痛分级指数（pain rating index，PRI）、视觉模拟评分（visual analogous scale，VAS）和现有疼痛强度评分（present pain intensity，PPI）3部分，三者的累积分值作为疼痛系数。结果服药组的PRI为3．8333±2．3057，对照组为4．3333±3．1132，（P〉0．05）。服药组的VAS为（2．6167±1．1347）分，对照组为（3．2333±0．5942）分，（P〈0．05）。服药组的PPI为（1．3667±0．6149）分，对照组为（1．1111±0.7511）分，（P〉0．05）。服药组的疼痛系数为7．8167±3．4046，对照组为8．6778±3．5499，（P〉0．05）。二者差异无统计学意义。结论应用尼美舒利超前镇痛法对于缩减PRP疼痛的方法是不明显的。Objective To evaluate the effectiveness of nimesulide for the reduction of pain in panretinal photocoagulation （PRP）. Methods A double-masked randomized controlled study was per-formed. Fifty-eight eyes in 48 patients undergoing PRP were enrolled and randomised to group nime-sulide or placebo, taken for 2 days starting 24 hours before the laser treatment. The laser treatment was performed following a standardized protocol. Pain after treatment was assessed using Short form of the McGill pain questionnaire （SF-MPQ）, it included pain rating index （PRI）, visual analogous scale （VAS） and present pain intensity （PPI）. The score of them was the pain level. Results The PRI for group nimesulide was 3.8333±2.3057 and group placebo was 4.3333±3.1132, （P 〉0.05）. The VAS for group nimesulide was 2.6167±1.1347 and group placebo was 3.2333±0.5942, （P 〈0.05）. The PPI for group nimesulide was 1.3667±0.6149 and group placebo was 1.1111±0.7511, （P 〉0.05）. The mean pain level for group nimesulide was 7.8167±3.4046 and group placebo was 8.6778±3.5499, （P 〉0.05）. There was no significant difference for pain levels between nimesulide instilled and place-bo eyes （P 〉0.05）. Conclusions Pre-emptive analgesia with nimesulide dose not significantly reduc-es pain associated with PRP.

关 键 词：疼痛 全视网膜光凝术 尼美舒利 SF—MPQ 

分 类 号：R587.2[医药卫生—内分泌]