和厚朴酚自微乳化给药系统的研究  

Development of self-microemulsifying drug delivery system for honokiol

作　　者：甘露[1] 田睿[2] 郭锋[3] 王春晖[3] 左的于[3] 张良珂[1] 

机构地区：[1]重庆医科大学药学院药剂学教研室,400016 [2]重庆医科大学实验教学中心药学组 [3]基础医学院救援医学系重庆医科大学

出　　处：《第三军医大学学报》2013年第19期2073-2076,共4页Journal of Third Military Medical University

基　　金：重庆市自然科学基金(CSTC2012jjA10021);高等学校博士学科点专项科研基金(20125503120003);重庆医科大学大学生科研与创新实验项目(201244,201229,201217)~~

摘　　要：目的筛选并优化了和厚朴酚自微乳化给药系统(honokiol-SMEDDS)的处方。方法利用溶解度,辅料配伍实验及伪三元相图筛选空白处方,以粒径和体外释放评价为指标选取最佳处方。结果优化后的honokiol-SMEDDS处方油相为辛癸酸甘油酯(MCT),表面活性剂为聚氧乙烯氢化蓖麻油(Cremophor RH40),助表面活性剂为二乙二醇单乙基醚(Transcutol P),油相比例20%,表面活性剂与助表面活性剂的比值K m为2,载药量为10%,平均粒径为28 nm。结论成功制备了honokiol-SMEDDS,显著提高了和厚朴酚的溶解度。Objective To screen and optimize the formulation of self-microemulsifying drug delivery system （SMEDDS） for honokiol. Methods The formulation of honokiol-SMEDDS was screened by solubility experiment, compatibility test for excipients and pseudo-ternary phase diagrams. And the best formulation was determined by the particle size and in vitro release evaluation. Results In the best formulation of honokiol- SMEDDS, octyl and decyl glycerate （MCT）, polyoxyethylene hydrogenated castor oil （Cremophor RH40） and diethylene glycol monoethyl ether （Transcutol P） were used as oil phase, surfactant and co-surfactant, respec- tively. The percentage of oil phase was 20%, Km of surfactant to cosurfactant was 2, the drug loading was 10%, and the average particle size was 28 nm. Conclusion The honokiol-SMEDDS is prepared successfully, and the solubility of honokiol is improved significantly.

关 键 词：和厚朴酚 自微乳化给药系统 伪三元相图 

分 类 号：R284.1[医药卫生—中药学] R943[医药卫生—中医学]