308单频准分子紫外光治疗无色素痣的临床疗效观察  被引量:4

Clinical observation on 308-nm monochromatic excimer light for the treatment of amelanotic nevus

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作  者:马慧军[1] 宋联进[1] 杨扬[1] 胡蓉[1] 张明月[1] 高鹏飞[1] 王婧毅[1] 

机构地区:[1]解放军第309医院皮肤科,北京100091

出  处:《中华皮肤科杂志》2013年第10期751-752,共2页Chinese Journal of Dermatology

基  金:国家自然科学基金(81271774)

摘  要:目的探讨308单频准分子紫外光对无色素痣的疗效及其不良反应。方法308单频准分子紫外光对18例躯干部无色素痣的患者进行连续10次治疗,治疗前后检测皮损平均黑素值,随访3个月。结果同初次治疗前基线值相比,治疗后皮损平均黑素值以次数依赖方式逐渐上升;约6次治疗后,皮损平均黑素值与周围正常皮肤平均黑素值百分率接近100%,随着随访时间的延长,皮损平均黑素值有下降趋势,约1个月后,皮损平均黑素值接近周围正常皮肤,3个月后皮损平均黑素值是正常皮肤的90%。治疗期间未发现水疱和瘢痕形成等不良反应。结论308准分子紫外光治疗无色素痣安全有效,为稳定疗效可间隔3个月巩固治疗1次。Objective To evaluate the efficacy and safety of 308-nm monochromatic excimer light for the treatment of amelanotie nevus. Methods Eighteen patients with amelanotic nevus were treated with 308-nm monochromatic excimer light twice a week for five consecutive weeks. Melanin content index (MCI) was measured in the lesions before and after the treatment. After the final exposure, a three-month follow-up was carried out. Results After the start of treatment, the MCI in lesions increased in a session-dependent manner and approximated to 100% of that in perilesional normal skin after six sessions of treatment. The follow-up revealed a decrease trend in MCI after the end of the treatment, which was nearly equal to that in perilesional normal skin one month later, and dropped to about 90% of that three months later. No side effects such as blisters or scar were observed during the treatment. Conclusions The 308-nm monochromatic excimer light is safe and effective for the treatment of amelanotic nevus. Re-exposure to 308-nm monochromatic excimer light after three months is recommended as consolidation therapy.

关 键 词:疗效观察 光治疗 色素痣 准分子 紫外光 临床 正常皮肤 不良反应 

分 类 号:R758.5[医药卫生—皮肤病学与性病学]

 

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