纳米药物递释系统的脑靶向研究进展  

Research advances in brain-targeted nanoscale drug delivery system

作　　者：刘洋[1] 蒋晨[1] 

机构地区：[1]复旦大学药学院智能化递药教育部重点实验室,上海201203

出　　处：《药学学报》2013年第10期1532-1543,共12页Acta Pharmaceutica Sinica

摘　　要：血脑屏障在发挥中枢神经系统保护作用的同时也阻碍了诊断和治疗药物向脑部的递送。随着纳米技术的发展,纳米药物载体系统的应用使药物的跨血脑屏障转运和脑内递释成为可能。脑靶向药物递释系统由两个基本部分组成:药物的递释载体系统和脑靶向策略。本文将主要介绍几种用于脑靶向药物递释的载体,重点介绍实现药物脑靶向递送的几种脑靶向策略,并对其各自的特点进行评价。The blood-brain barrier （BBB） exerts its central nervous system （CNS） protective function as it hinders the delivery of diagnostic and therapeutic agents to the brain. With the development of nanotechnology during the last thirty years, the nanocarriers for delivering drugs make it possible to transport drugs across the BBB. The brain-targeted drug delivery system usually consists of two parts： nanocarriers and brain-targeted strategies. In this review, several kinds of nanocarriers are introduced for brain-targeted drug delivery. We focus on several possible strategies for brain-targeting and comment on their advantages and disadvantages in application.

关 键 词：靶向药物 纳米药物 血脑屏障 脑部疾病 

分 类 号：R943[医药卫生—药剂学]