吸烟对慢性阻塞性肺疾病患者凝血功能及IL-6和hs-CRP的影响  

Effects of smoking on coagulation function,interleukin-6( IL-6) and high-sensitivity c-reactive protein( hs-CRP) in patients with chronic obstructive pulmonary disease

作　　者：王红阳[1] 张丽丽[1] 刘飒[1] 黄艳[1] 喻昌利[1] 闫丽[1] 

机构地区：[1]河北联合大学附属医院呼吸内科,河北唐山063000

出　　处：《中华疾病控制杂志》2013年第10期891-894,共4页Chinese Journal of Disease Control & Prevention

基　　金：河北省医学科研重点课题(08412)

摘　　要：目的探讨吸烟对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者凝血功能及白细胞介素6(interleukin-6,IL-6)及超敏C反应蛋白(high-sensitivity c-reactive protein,hs-CRP)水平的影响。方法慢性阻塞性肺疾病急性加重期住院患者90例作为病例组、100例健康体检者作为对照组。采用酶联免疫吸附测定(enzyme linked immunosorbent assay,ELISA)检测血清凝血四项及D二聚体、hs-CRP,放射免疫法(Radioimmunoassay,RIA)分别测血清IL-6,比较检测指标在COPD加重期、缓解期及健康对照组的差异;比较检测指标在两组中吸烟者与不吸烟者之间的差异。结果病例组纤维蛋白原及D二聚体变化趋势与IL-6及hs-CRP相同,以上四项指标病例组明显高于对照组、病例组加重期显著高于缓解期、吸烟者显著高于不吸烟者;对照组吸烟者显著高于不吸烟者(均有P<0.05)。结论吸烟与COPD加重期气道炎症和高凝状态有关,吸烟是影响COPD加重期病情稳定的重要因素,应倡导患者戒烟和尽早抗凝治疗。Objective To explore the influence of smoking on coagulation function and interleukin-6 （IL-6）and high-sensitivity c-reactive protein （hs-CRP） in patients with chronic obstructive pulmonary disease.,. Methods 90 hospital- ized patients with chronic obstructive pulmonary disease in acute exacerbation （ AECOPD ） were included as the case group, 100 healthy persons were selected as control group. The levels of blood coagulation and D dimers and hs-CRP were measured by ELISA. The levels of blood IL-6 were measured by RIA. Results The variation trend of the Fibrinogen and D dimers was the same as that of IL-6 and hs-CRP in patients. Fibrinogen and D dimers levels were significantly higher in case group than that in control group, the indexes above were significantly higher in acute exacerbation period than that of remission, higher in smokers than that of non-smokers in the case group and in control group these were also significantly higher in smokers than non-smokers （P 〈 0. 05）. Conclusions Smoking is related with the airway inflammation and high condensation state caused by COPD. Smoking is a stable condition, which is important factor affecting COPD. COPD pa- tients should give up smoking and accept anticoagulant therapy as soon as possible.

关 键 词：肺疾病 慢性阻塞性 吸烟 白细胞介素6 

分 类 号：R563[医药卫生—呼吸系统] R181[医药卫生—内科学]