表观遗传对视网膜神经节细胞发育及凋亡的调控  

The modulation of epigenetic on the devel opment and apoptosis of retinal ganglion cells

作　　者：陈歆雅[1] 张圣海[1] 吴继红[1] 

机构地区：[1]复旦大学附属眼耳鼻喉科医院眼科,上海市200013

出　　处：《眼科新进展》2013年第10期994-997,共4页Recent Advances in Ophthalmology

摘　　要：表观遗传学是一种仅涉及到基因表型而不依赖于基因序列的改变,并能够稳定遗传的基因表达调节方式,包括DNA甲基化、组蛋白乙酰化修饰和非编码RNAs的调控等。表观遗传调节方式的研究进一步推进对许多疾病发病机制的了解,本文着重概括了表观遗传影响视网膜神经节细胞的发育以及凋亡过程的相关研究进展。Epigenetic is defmed as a stable inheritable way of gene expression and regulation which only involves gene phenotype and is independent of the change of gene sequences,it includes DNA methylation, the decoration of histone acetylation and the modulation of non-coding RNA. The study of epigenetic regulation further promotes the understanding of the pathogenesis of many diseases. This paper mainly reviews related research progress of epigenetic on the development and apoptosis of retinal ganglion cells.

关 键 词：表观遗传 DNA甲基化 组蛋白乙酰化 视网膜神经节细胞 

分 类 号：R775[医药卫生—眼科]