2-甲氧基吴茱萸次碱合成工艺改进  

An Improved Synthesis of 2-Methoxy Rutaecarpine

作　　者：王学成 朱建民 

机构地区：[1]江苏省兽用抗寄生虫药物工程技术研究中心,江苏常州213127

出　　处：《浙江化工》2013年第9期16-17,共2页Zhejiang Chemical Industry

摘　　要：以吲哚为起始原料,与丙烯酸发生Michael加成反应制得吲哚丙酸,然后通过酰化、叠氮化、Curtius重排、环合反应得到咔啉,最后与2-氨基-4-甲氧基苯甲酸在脱水剂作用下环合制成2-甲氧基吴茱萸次碱。Indole propionic acid was prepared from indole via Michael addition reaction with acylic acid, then Carboline was synthesized through Acylation, azido reaction, Curtius rearrangement, cyclization reaction, finally the cyclization of Carboline with 2-amino-4-methoxy benzoic acid in the presence of dewatering agent provided the target compound 2-methoxy rutaecarpine.

关 键 词：MICHAEL加成 Curtius重排 环合反应 酰基叠氮 2-甲氧基吴茱萸次碱 

分 类 号：TQ463[化学工程—制药化工]