氟比洛芬酯联合舒芬太尼镇痛对大肠癌根治术围术期患者T淋巴细胞亚群及自然杀伤细胞的影响  

Influence of Combination Analgesia of Flurbiprofen Axetil and Sufentanil on the Subsets of T Lymphatic Cells and Natural Killer Ceils of the Perioperative Patients Undergoing the Radical Procedure for Large Intestinal Cancer

作　　者：伍玉哲[1] 

机构地区：[1]大连大学附属中山医院麻醉科,辽宁大连116001

出　　处：《中国肛肠病杂志》2013年第8期13-16,共4页Chinese Journal of Coloproctology

摘　　要：为探讨氟比洛芬酯联合舒芬太尼镇痛对大肠癌根治术患者围术期外周血T淋巴细胞亚群及自然杀伤（NK）细胞的影响，将40例择期全麻下行大肠癌根治术的患者随机分为A、B两组，术前30min两组分别静脉推注氟比洛芬酯lmg／kg（A组）和安慰剂英脱利匹特（B组），术后距第一次给药6h追加相应药物1次，术后两组均以舒芬太尼行患者自控静脉镇痛（PCIA）；对比观察两组患者麻醉前、手术开始后2h及术后24h、48h、120h五个时间点的T淋巴细胞亚群（CD3＋、CD4＋、CD8。）及NK细胞（CD3-、CDl6＋、CD56＋）水平。结果显示，与麻醉前比较，两组CD3＋、CD4＋、CD4＋／CD8＋和NK细胞水平在手术开始后2h及术后48h均明显降低（P〈O．05）；术后120hNK细胞水平仍未恢复至麻醉前水平（P〈O．05）。与B组比较，A组CD3＋、CD4＋、CD4＋。／CD8＋和NK细胞水平在术后24h下降幅度较小（P〈0．05）。结果表明，与单用舒芬太尼镇痛相比，大肠癌根治术患者应用氟比洛芬酯联合舒芬太尼镇痛对其围术期T淋巴细胞亚群和NK细胞有保护作用。The objective of this study was to explore the influence of analgesia of Flurbiprofen axetil com- bined with Sufentanil on the perioperative subsets of T lymphatic cells and natural killer cells （NK） of the patients undergoing the radical surgery for large intestinal cancer. The 40 patients to be subjected to sched- uled radical surgery for large intestinal cancer under systemic anesthesia were randomly divided into group A and B. At 30min before operation group A received Flurbiprofen axetil lmg/kg,B placebo （intralipid） in- travenously,after 6 hours again was added responsible drugs one time; after operation both groups all a- dopted patient controlled intravenous analgesia（PCIA） with Sufentanil; Then the levels of T lymphatic cells （CD3＋ ,CD4＋ and CD8~） ,as well as NK cells （CD3- ,CD16＋ and CD56＋） of patients of both groups before anesthesia,at 2h（T1） after operation started, and at 24h（T2）,48h（T3）,120h（T4） after operation were compared and observed. As results, compared with that of before anesthesia CD3＋ ,CD4＋ and CD4＋/ CD8＋ ,as well NK cells at T1 and T3 in both groups were significantly decreased（ P 〈0.05） ;and at T4 the level of NK cells did not recovery till the level before anesthesia （ P 〈0.05） compared with group B,the levels of CD3＋, CD4＋ and CD4＋/CD8＋ ,as well NK cells of group A became less decrease scope（ P 〈0.05） at T2. Results show that compared with alone Sufentanil above combination analgesia has a protec- tion for perioperative T lymphatic cells subsets and NK cells of the patients undergoing the radical surgery for larger intestinal cancer.

关 键 词：大肠癌 氟比洛芬酯 舒芬太尼 T淋巴细胞亚群 NK细胞 

分 类 号：R725.622.5[医药卫生—儿科]