SMV在SDBS自组装膜与RGO复合修饰碳糊电极上的电催化氧化及电分析研究  

Electrocatalytic oxidation of simvastatin at SDBS self-assembled monolayers and RGO modified carbon paste electrode and its electrochemical determination

作　　者：张瑞[1] 张青春[1] 段春玲[1] 彭娟[1] 高作宁[1] 

机构地区：[1]宁夏大学化学化工学院,宁夏银川750021

出　　处：《化学研究与应用》2013年第9期1245-1250,共6页Chemical Research and Application

基　　金：国家自然科学基金项目(21265014)资助

摘　　要：研究了辛伐他汀(SMV)在表面活性剂十二烷基苯磺酸钠(SDBS)自组装膜与石墨烯(RGO)复合修饰碳糊电极(SDBS-RGO/CPE)上的电催化氧化和电化学动力学性质。实验结果表明,SDBS-RGO/CPE对SMV电化学氧化具有良好的催化作用。同时用循环伏安法(CV),计时电流法(CA)测定了SMV在SDBS-RGO/CPE上的电极反应动力学参数,用方波伏安法(SWV)测得SMV氧化峰电流(I pa)与其浓度在6.0×10-5～4.5×10-4mol·L-1范围内呈良好线性关系,检测限(S/N=3)为5.0×10-6mol·L-1,同时运用该方法对市售辛伐他汀片剂中SMV含量进行了电化学定量测定,测定结果符合定量测定要求。Eleetrocatalytic oxidation and electrochemical kinetics of simvastatin （SMV）were investigated at sodium dodeeyl benzenesulfonate（SDBS） self-assembled monolayers and graphene （RGO）modified carbon paste electrode（SDBS-RGO/CPE）. The experimental results showed that SDBS-RGO/CPE showed an excellent electroeatalytic activity towards SMV electrochemical oxidation. The electrochemical kinetic parameters were also determined by cyclic voltammetry （ CV ） and ehronoamperometry （ CA ）. The oxidation peak current of catalytic oxidation of SMV versus its concentration had a good linear relationship in the concentration range of 6.0 × 10^-5 mol. L^-1 - 4. 5 × 10^-4 mol. L^-1 and the detection limit of 5.0 ×10^-6 mol. L^-1 （ S/N= 3 ） by square wave voltammetry （SWV）. At the same time the supposed method have been applied in the electrochemical quantitative determination of SMV content in commercial tablet samples and the determination results meet the requirement of the quantitative determination.

关 键 词：辛伐他汀 十二烷基苯磺酸钠 石墨烯 修饰碳糊电极 电催化氧化 电分析方法 

分 类 号：O657.1[理学—分析化学]