阿拉坦五味丸治疗功能性消化不良的疗效观察  

Efficacy Observation of Alatan Wuwei Pills in the Treatment of Functional Dyspepsia

作　　者：鲁厚胜[1] 陈秀英[1] 

机构地区：[1]重庆市第九人民医院,重庆400700

出　　处：《中国药房》2013年第35期3333-3335,共3页China Pharmacy

摘　　要：目的：观察阿拉坦五味丸治疗功能性消化不良的临床疗效。方法：将84例功能性消化不良患者随机分为治疗组42例和对照组42例,其中对照组给予基础治疗：多潘立酮10 mg,每日3次,奥美拉唑20 mg,每日1次;治疗组在对照组基础上加用阿拉坦五味丸11~15粒,每日1~2次。两组疗程均为4周。比较两组的临床总有效率、治疗前后症状积分、临床症状改善情况、幽门螺杆菌（Hp）根除情况和不良反应。结果：治疗组的总有效率明显高于对照组（χ2=5.49,P〈0.05）;治疗后治疗组的症状积分较对照组明显下降（t=3.11,P〈0.05）,症状改善情况明显优于对照组（χ2=5.13、5.33、4.21、4.86、4.10、4.38,P〈0.05）;治疗组的Hp根除率明显高于对照组（χ2=4.09,P〈0.05）。两组不良反应发生率比较差异无统计学意义（χ2=0.12,P〉0.05）。结论：基础治疗加用阿拉坦五味丸治疗功能性消化不良的疗效较好,且不良反应小。OBJECTIVE：To observe the clinical efficacy of Alatan wuwei pills in the treatment of functional dyspepsia.METHODS：84 functional dyspepsia patients were randomly divided into treatment group（42 cases）and control group（42 cases）.The control group was given foundation treatment of domperidone 10 mg 3 times a day and omeprazole 20 mg once a day;while the treatment group additionally received 11-15 pieces of Alatan wuwei pills 1-2 times a day for 4 weeks based on the above treatment.Total effective rate,symptom score,the improvement of clinical symptom,Hp eradication and ADR were compared between 2 groups.RESULTS：The total effective rate of treatment group was significantly higher than that of control group（χ2=5.49,P 0.05）;symptom score decreased significantly after treatment,compared with the control group（t=3.11,P〈0.05）;the improvement of symptoms in treatment group was significantly better than in control group（χ2=5.13,5.33,4.21,4.86,4.10,4.38,P〈0.05）;Hp eradication of treatment group was significantly higher than that of control group（χ2=4.09,P〈0.05）.There was no statistical significance in the incidence of ADR between 2 groups（χ2=0.12,P〈0.05）.CONCLUSIONS：Foundation treatment combined with Alatan wuwei pills have better curative efficacy and less adverse drug reactions.

关 键 词：阿拉坦五味丸 功能性消化不良 奥美拉唑 多潘立酮 

分 类 号：R283.64[医药卫生—中药学] R975[医药卫生—中医学]