肾活检病理资料6995例分析  

Analysis of 6995 renal biopsy

作　　者：吴歌[1] 邢国兰[1] 权松霞[1] 周雅丽[1] 刘章锁[1] 

机构地区：[1]郑州大学第一附属医院肾内科郑州大学肾脏病研究所,郑州450052

出　　处：《中国实用内科杂志》2013年第9期728-730,共3页Chinese Journal of Practical Internal Medicine

摘　　要：目的了解肾脏病患者病理的流行病学特点，为肾脏病防治提供理论依据。方法回顾性分析2009年1月至2011年12月间就诊于郑州大学第一附属医院肾病风湿科行肾穿刺活检的6995例患者的病理资料。结果（1）6995例患者中，男3636例，女3359例；20—49岁为高发年龄段，共4272例（61．07％）；男性患者发病早于女性（P=0．001）。（2）原发性肾小球疾病（PGD）4638例（66．30％），继发性肾小球疾病（SGD）2191例（31．32％），肾小管间质疾病166例（2．37％）。PGD病理以IgA肾病为主（40．34％），其次为肾小球微小病变（24．29％）、膜性肾病（13．97％）等。（3）继发性肾小球肾炎以狼疮性肾炎最多见，为34．73％，其次为过敏性紫癜性’肾炎（19．58％）、乙型肝炎病毒相关性肾炎（13．33％）、不典型膜性肾病（10．77％）等。（4）血管性疾病导致的肾小球疾病中，缺血性肾损伤最常见（4．84％），其次为恶性高血压肾损害（3．47％）、高血压良性肾小动脉硬化症（1．69％）等。（5）代谢性疾病导致的肾小球疾病中，糖尿病肾病最多见（4．84％），其次为淀粉样变性肾病（3．01％）、肥胖相关性肾小球疾病（1．55％）等。结论肾活检疾病的高发人群为青壮年，以PGD最常见，其中IgA肾病是最常见的PGD。狼疮性肾炎是最常见的SGD。Objective To explore epidemiological characteristics of Henan province kidney disease pathology in order to provide theoretical basis for diagnosis and treatment of kidney diseases. Methods To retrospectively analyse the renal path-ological data of 6995 patients in our hospital who had renal biopsy from January 2009 to December 2012. Results （ 1 ） The average age at renal biopsy was 34. 46 ± 16. 71 （1-93 ）years old within 6995 patients （male 3636 and female 3359 ）, it mainly occurred in the age group 20-49 y, gender ratio was 1.08： 1, and the male patients were earlier than the female ones （ P = 0. 001 ） ; （ 2 ） Primary giomerular diseases （ PGD ） accounted for 66. 30%, secondary glomerular diseases （ SGD ） for 31.32% ,and tubular-interstitial diseases for 2. 37%. The PGD in descending order of incidence were IgA nephropathy （IgAN 40. 34% ） ,Minimal change glomerular disease （ MCD 24. 29% ） and membranous nephropathy （ MN 13.97% ） ; （3） The SGN in descending order of incidence were lupus nephritis （LN 34. 73% ）, Henoch Schonlein purpura nephritis （HSPN 19.58% ） , hepatitis B virus-associated nephritis （ HBVGN 13.33% ） and atypical membranous nephropathy （ 10. 77% ） ;（4）The glomerular diseases induced by vascular disease in descending order of incidence were ischemic renal injury（4. 84% ）, malignant hypertensive renal damage （3.47%） , benign hypertensive renal arteriosclerosis （ 1.69% ）and so forth ; （5） The glomerular diseases induced by metabolic diseases in descending order of incidence were diabetic nephropa-thy（ DN 4. 84% ） ,then,renal amyloidosis（3.01% ） ,obesity-related kidney disease（ 1.55% ） and so on. Conclusion Re-nal diseases often happened in young people in Henan province, and PGD was a dominating type in which IgA nephropathy was the most common, and the male patients suffered younger than the female ones. Lupus nephritis was the most common pathological type of SGD which occurred more frequently in female

关 键 词：肾活检 病理 原发性肾小球疾病 肾小管间质疾病 糖尿病肾病 

分 类 号：R692.6[医药卫生—泌尿科学]