改性海藻酸纳米胶囊对氯氟氰菊酯的释放性能  

Properties of Nanocapsules Prepared by Modified Sodium Alginate in the Release of Cyhalothrin

作　　者：颜慧琼[1] 李嘉诚[1] 冯玉红[1] 胡文涛[1] 程春风[1] 林强[1,2] 

机构地区：[1]海南大学材料与化工学院化工系,海南海口570228 [2]海南师范大学,海南海口571100

出　　处：《精细化工》2013年第9期975-980,984,共7页Fine Chemicals

基　　金："十二五"国家科技支撑计划资助项目(2011BAE06A06-7;2011BAE06B04-7);海南省重点科技计划资助项目(ZDXM20120003);海口市重点科技计划项目(2011-0104)~~

摘　　要：以DCC／DMAP偶联反应将胆固醇基接枝到天然多糖海藻酸钠上，制备了胆固醇基接枝海藻酸钠衍生物（CSAD），采用乳化法对氯氟氰菊酯进行了负载，得到载药纳米胶囊。通过FTIR、^1HNMR、荧光光谱、动态光散射、TEM和释药实验分别对改性海藻酸钠的结构和疏水性能以及载药纳米胶囊的形貌结构和释药性能进行了表征。结果表明，改性海藻酸钠的取代度为5．3％～7．9％，其临界聚集质量浓度由1．23mg／L降为0．26～0．63mg／L，且随着取代度的增大，疏水基的增多，临界聚集质量浓度降至更低。所制备的载药纳米胶囊的d50为（576．4±7．4）nm。Zeta电位值为（-32．3±0．6）mV，在水溶液中能够表现出极好的稳定性能。对比常规AEOn微乳剂，CSAD的氢键作用是CSAD纳米胶囊具备缓释性能的关键因素。Cholesterol modified alginate （CSAD） was prepared by covalent attachment of hydrophobic cholesterol onto the natural polysaccharide alginate. And the cyhalothrin-loaded nanocapsules were obtained by emulsification method. The structure and hydrophobic properties of the alginate derivative and the morphology and release properties of the nanocapsules were characterized by means of FTIR, i HNMR, fluorescence spectrum, dynamic light scattering, transmission electron microscopy （TEM） and release studies. The experimental results show that the degree of substitution of CSAD was 5.3% -7.9% and their critical aggregation mass concentration decreased from 1.23 mg/L to 0. 26 0. 63 mg/L. With the increasing degree of substitution, the hydrophobic group increased and the critical aggregation mass concentration decreased. The d50 of the drug-loaded nanocapsules was （576. 4 _＋ 7.4） nm, and the Zeta potential value of drug-loaded nanocapsules was （ - 32. 3 _＋ 0.6） mV,which could exhibit excellent stability in aqueous solution. Compared with conventional microemulsions, the hydrogen bonds were the key factors in CSAD nanocapsules＇ slow-release properties.

关 键 词：海藻酸钠 胆固醇 氯氟氰菊酯 CSAD 缓释剂型 纳米胶囊 功能材料 

分 类 号：TQ453.292[化学工程—农药化工]