血管紧张素转换酶基因插入缺失多态性与原发性高血压患者合并心房颤动的相关性研究  

Correlation between angiotensin converting enzyme gene insertion deletion polymorphism and AF in patients with primary hypertension

作　　者：靳钰[1] 邱春光[1] 侯允天[2] 王志方[3] 刘志强[3] 

机构地区：[1]郑州大学第一附属医院心内科,450052 [2]解放军总医院老年心血管病研究所 [3]新乡市中心医院心内科

出　　处：《中华老年心脑血管病杂志》2013年第9期906-908,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的 探讨中国河南豫北地区汉族原发性高血压人群血管紧张素转换酶（ACE）基因插入（I）/缺失（D）多态性与心房颤动（房颤） 的关系.方法 采用病例对照法,选择原发性高血压患者803例,分为房颤组405例和窦性心律组398例,采用PCR-RFLP方法进行ACE基因I/D多态性分析.结果 房颤组DD基因型频率明显高于窦性心律组（25.9% vs 13.1%）,ID基因型频率明显低于窦性心律组（38.8% vs 50.3%,P〈0.05）.与携带II＋ID基因型者比较,携带DD基因型高血压患者房颤的风险增加（OR=2.13,95%CI：1.60-3.29,P〈0.05）,携带DD基因型的高血压合并房颤患者左心房内径明显扩大,LVEF明显降低（P〈0.05）.结论 ACE基因I/D多态性与原发性高血压患者房颤的发生存在相关性,DD基因型可能使高血压患者发生房颤的危险增加.Objective To study the correlation between angiotensin converting enzyme （ACE） gene insertion/deletion （I/D） polymorphism and atrial fibrillation （AF） in patients with primary hyper- tension in the northern part of Henan Province,China. Methods Eight hundred and three patients with primary hypertension were divided into AF group （n =405） and sinus rhythm group （n = 398）. ACE gene I/D polymorphism was detected by PCR-RFI.P. Results The DD genotype fre quency was significantly higher and the ID genotype frequency was significantly lower in AF group than in sinus rhythm group （25.9% vs 13.1%,38.8% vs 50.3%,P〈0.05）. The risk of AF was significantly higher in patients with primary hypertension carrying DD genotype than in those carrying II＋ID genotype （OR： 2.13,95 %CI：I. 60--3.29, P〈0.05）. The inner diameter of left atrium was significantly longer and the LVEF was significantly lower in hypertensive patients with AF carrying DD genotype than in those carrying II＋ID genotype （P〈0.05）. Conclusion ACE gene I/D polymorphism is correlated with AF and DD genotype can increase the risk of AF in patients with primary hypertension.

关 键 词：肽基二肽酶A 诱变 插入 高血压 心房颤动 多态性 单核苷酸 基因型 

分 类 号：R544.1[医药卫生—心血管疾病]