内皮素1与冠状动脉钙化的相关性研究  

Correlation between endothelin-1and coronary artery calcification

作　　者：卿平[1] 李怡霖[1] 贾燕珺[1] 李小林[1] 刘俊[1] 郭远林[1] 朱成刚[1] 徐瑞霞[1] 李建军[1] 

机构地区：[1]中国医学科学院中国协和医科大学阜外心血管病医院心内科,北京100037

出　　处：《中华老年心脑血管病杂志》2013年第9期916-919,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家自然科学基金(81070171)

摘　　要：目的 探讨内皮素1与冠状动脉钙化（coronary artery calcification,CAC）的相关性.方法 连续收集2011年2月-2012年2月具有冠状动脉造影和CT结果的临床资料完整的患者424例,按照是否存在CAC分为钙化组（353例）与非钙化组（71例）,分析内皮素1与CAC的相关因素.结果 与非钙化组比较,钙化组的冠心病、糖尿病、高血压和高脂血症患者显著增多（P=0.001）,糖化血红蛋白（HbA1c）、高敏C反应蛋白和内皮素1升高（P=0.002,P=0.001,P=0.001）差异有统计学意义.logistic回归分析显示,年龄、内皮素1、高血压、高脂血症和HbA1c与CAC独立相关,差异有统计学意义.在ROC曲线下,CAC的最佳内皮素1界值为0.59（曲线下面积为0.65,95%CI：0 58-0 72）,敏感性为50.1%,特异性为76.1%.结论 内皮素1与CAC有一定的相关性,可认为是CAC的独立预测因素之一.Objective To study the correlation between endothelin-1 （ET-1） and coronary artery calcification （CAC）. Methods Four hundred and twenty-four patients who underwent coronary angiography and CT in Fuwai Cardiovascular Diseases Hospital from February 2011 to February 2012 were divided into CAC group （n=353） and non-CAC group （n=71）. Correlation between ET-1 and CAC was analyzed. Results The incidence of diabetes mellitus,hypertension,hyperlipi- demia and the serum levels of HbAlc,hs-CRP,ET-1 were significantly higher in CAC group than in non-CAC group （P = 0. 002, P = 0. 001, P = 0. 001）. Logistic regression analysis showed that age, ET-1, hypertension, hyperlipidemia and HbAlc were independently correlated with CAC. The optimal ET-1 value of CAC was 0.59 （AUC=0. 65,95%CI：0. 58--0. 72） with a sensitivity of 50. 1% and a specificity of 76.1%. Conclusion ET-1 is correlated with CAC and can thus be considered as an independent predictor for CAC.

关 键 词：内皮缩血管肽1 冠状动脉疾病 肌 平滑 血管 钙质沉着症 C反应蛋白质 高血压 糖尿病 ROC曲线 

分 类 号：R543[医药卫生—心血管疾病]