老年隐性高血压患者家庭自测血压变异性与颈动脉粥样硬化的相关性  

Correlation between self-measured blood pressure variability and carotid atherosclerosis in elderly masked hypertensive patients

作　　者：郭芳[1] 赵颖馨[2] 曹春林[1] 刘振东[2] 

机构地区：[1]山东大学附属省立医院心内科,济南250021 [2]山东省医学科学院基础医学研究所心脑血管病防治研究中心

出　　处：《中华老年心脑血管病杂志》2013年第9期937-940,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：山东省自然科学基金(ZR2011HQ053);山东省科技发展计划项目(2011GSF11822)

摘　　要：目的探讨老年隐性高血压患者家庭自测血压变异性与颈动脉粥样硬化及尿微量白蛋白(MAU)的关系。方法选择老年体检者197例,根据受试者诊室血压及7d家庭自测血压测定结果,将受试者分为血压正常组62例、隐性高血压组62例及高血压组73例。所有受试者均进行颈动脉内膜中层厚度(IMT)、硬化系数β值及MAU检测。结果隐性高血压组和高血压组诊室收缩压、自测收缩压、自测舒张压、收缩压变异性、舒张压变异性、IMT、硬化系数β值、MAU明显高于血压正常组(P<0.05,P<0.01);隐性高血压组诊室收缩压、诊室舒张压、自测收缩压、硬化系数β值明显低于高血压组(P<0.05,P<0.01)。隐性高血压患者自测血压变异性与IMT、硬化系数β值及MAU呈正相关。收缩压变异性是IMT、硬化系数β值及MAU的独立影响因素。结论老年隐性高血压患者家庭自测血压变异性升高,并与颈动脉粥样硬化及MAU相关。Objective To study the correlation of self-measured blood pressure variability with carotid atherosclerosis and microalbuminuria in elderly masked hypertensive patients. Methods One hundred and ninety-seven elderly masked hypertensive patients were divided into normotension group （n=62）,masked hypertension group （n=62）,and hypertension group （n=73） according to their blood pressure. Their IMT,carotid atherosclerosis index ; and microalbuminuria were recorded. Results The systolic blood pressure measured at our department,self-measured systolic and diastolic blood pressure and their variability, carotid IMT, carotid atherosclerosis index β and microalbuminuria were significantly higher in masked hypertension group and hypertension group than in normotension group （P〈0.05, P〈0.01）. The diastolic blood pressure measured at our department, self-measured systolic blood pressure, and carotid atherosclerosis index ; were signifi- cantly lower in masked hypertension group than in hypertension group （P〈0.05 ,P〈0.01）. The self-measured systolic and diastolic blood pressure variability was positively correlated with carotid IMT, carotid atherosclerosis index ; and microalbuminuria. The systolic blood pressure variability was the independent influencing factor for IMT,carotid atherosclerosis index ; and microalbu-minuria. Conclusion Elevated self-measured blood pressure variability is correlated with carotid atherosclerosis and microalbuminuria in elderly masked hypertensive patients.

关 键 词：高血压 血压测定 血压监测 便携式 颈动脉疾病 动脉粥样硬化 危险因素 

分 类 号：R544.1[医药卫生—心血管疾病]