含丹参腹膜透析液对微炎症状态的干预作用  

Impacts of Danshen on Microinflammation in Peritoneal Dialysis Patients

作　　者：王永业 李若福 王成燎 

机构地区：[1]苍南县人民医院肾脏内科,浙江苍南325800

出　　处：《中华中医药学刊》2013年第9期2022-2023,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：温州市科技计划项目(Y20110007)

摘　　要：目的:观察维持性腹膜透析(CAPD)患者微炎症状态,探讨丹参对微炎症的影响。方法:38例CAPD患者随机分为对照组(常规透析)和治疗组(常规透析加丹参),分别测定各组基础以及透析3月后微炎症指标:白介素-6(IL-6),肿瘤坏死因子-α(TNF-α),超敏C反应蛋白(hs-CRP)以及血尿素氮(BUN)、血肌酐(Scr)、血清白蛋白(ALB)、血红蛋白(Hb)等。结果:(1)透析患者的hs-CRP、IL-6、TNF-α明显高于正常健康人;(2)治疗组患者3月后血清炎症因子hs-CRP、IL-6、TNF-α水平均降低(P<0.05);两组治疗后比较,差异有统计学意义(P<0.05);(3)两组患者治疗后血尿素氮(BUN)、血肌酐(Scr)、血清白蛋白(ALB)、血红蛋白(Hb)水平稳定,无明显变化(P>0.05)。两组治疗后比较,差异无统计学意义(P>0.05)。结论:CAPD患者普遍存在微炎症状态,丹参可有效地短期改善CAPD患者的微炎症状态,但对改善腹膜溶质转运功能无意义。Objective：To investigate the state of microinflammation in continuous ambulatory peritoneal dialysis （CAPD）patients and the impacts of Danshen on it. Methods ：38 CAPD patients were divided into control group（ no Dan- shen addition）and experimental group（ with Danshen in peritoneal fluid）, Interleukin -6 （IL- 6 ）, Tumour necrosis factor - α （ TNF - α）, C - reactive protein （CRP） , blood urea nitrogen （ BUN ）, serum creatinine （ Scr）, albumin （ ALB ） and he- moglobin （Hb） were observed before and 3 months after peritoneal dialysis. Result ： The blood levels of IL - 6, TNF - αand CRP were higher in CAPD patients than that in the normal people. Three months after peritoneal dialysis, the blood levels of IL- 6 ,TNF -αand CRP were degraded in experimental group（ P 〈 0.05 ） , and there was significant differences be- tween the two groups（ P 〈 0.05 ）. The blood levels of BUN, Scr, ALB and Hb were stable（ P 〉 0.05 ）, and there was no significant differences between them（ P 〉 0.05 ）. Conclusion：Microinflammation is universal in CAPD patients. Danshen can ameliorate the state of microinflammation, but it is of no use in improving peritoneal transport function.

关 键 词：腹膜透析 微炎症 丹参 C反应蛋白 

分 类 号：R285.6[医药卫生—中药学]