胰升血糖素样肽-1受体激动剂对周围神经系统的作用  

Effect of glucagon like peptide-1 receptor agonists on the peripheral nervous system

作　　者：郝明[1] 匡洪宇[1] 

机构地区：[1]哈尔滨医科大学附属第一医院内分泌科,150001

出　　处：《中国糖尿病杂志》2013年第9期855-856,共2页Chinese Journal of Diabetes

基　　金：国家自然科学基金面上项目(30873392);黑龙江省自然科学基金面上项目(D201253);中国博士后科学基金面上资助项目(20090451019);省博士后基金项目(LRB08-405)

摘　　要：胰升血糖素样肽-1(GLP-1)是肠道因进食而分泌的促胰岛素分泌肽,最早发现的胰升血糖素样肽-1是其受体(GLP-1R)激动剂。GLP-1R及GLP-1在神经系统都有广泛的表达。多项体内与体外实验证明GLP-1R可以促进神经细胞的存活,并且GLP-1及其类似物有营养保护神经等多种生理作用。GLP-1R及其激动剂在外周神经系统功能的多样性具体为周围神经保护作用、通过周围神经调节血糖、影响食欲、调节周围神经兴奋性等。GLP-1R激动剂可能会成为一种新型神经保护药物,它对周围神经的保护作用可以用于糖尿病周围神经病变(DPN)等周围神经变性疾病的治疗。The glucagon-like peptide-1 （GLP-1） found at the earliest was the GLP-1R agonists. It is secreted by intestine during eating, can promote insulin secretion. GLP-1R and GLP-1 have abundant expressions in the nervous system. Experiments in vitro and in vivo have proved that GLP-1R can prolong the nerve cells~ lifetime, and GLP-1 has nourishing and protecting functions for nerve. The functional diversity of GLP-1R and its agonists for peripheral nerve include protecting peripheral nerve, adjusting its excitement, regulating blood glucose, and affecting appetite through peripheral nerve. GLR-1R agonists will probably become a drug used for protecting nervous system. Its protective action for peripheral nerve can be adopted in the treatment of peripheral neuropathv, such as diabetic peripheral neuroDathv.

关 键 词：胰升血糖素样肽-1受体 胰升血糖素样肽-1 神经系统 糖尿病周围神经病变 

分 类 号：R587.1[医药卫生—内分泌]