开展抗菌药物临床应用专项整治活动前后医院抗菌药物管理与临床使用分析  

Management and clinical application of antibiotics in a certain gradeⅡ-A hospital before and after carrying out special rectification campaign for clinical application of antibiotics

作　　者：罗宗伟[1] 赵学会[1] 赵婷[1] 罗宗怀 余瑜[2] 

机构地区：[1]四川省西充县人民医院药剂科,四川西充县637200 [2]重庆医科大学药学院,重庆400016

出　　处：《中华医院感染学杂志》2013年第17期4242-4244,共3页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金面上项目(811720971)

摘　　要：目的分析医院开展抗菌药物临床应用专项整治活动前、后抗菌药物管理和临床使用情况,进行阶段性总结,为下一步推进整治活动提供依据。方法统计分析医院整治活动前6个月(2011年1-6月)和整治活动后6个月(2011年7-12月)抗菌药物供应目录,抗菌药物分级制度落实情况,住院患者抗菌药物使用率、使用强度、Ⅰ类手术切口预防使用抗菌药物比例等指标。结果整治活动前,医院抗菌药物品种为64种,剂型97个,整治活动后,医院抗菌药物品种压缩到35种,剂型减少到64个,整治活动前、后,抗菌药物使用费用占药品费用比例由39.43%降至29.76%,住院患者抗菌药物使用率由83.19%降至68.32%,抗菌药物使用强度由96.51DDD降至51.56DDD,联用抗菌药物的比例由48.34%降至27.22%,Ⅰ类手术切口预防使用抗菌药物比例由100.00%降低了45.37%,Ⅰ类手术切口预防使用抗菌药物术前30min^2h给药比例由57.15%升至89.73%,预防用药时间由129.61h缩短到55.28h,微生物送检率由15.40%升至26.73%,门诊抗菌药物使用率由54.48%降至25.27%。结论医院整治活动政策落实有力,制定的制度和措施符合实际并认真执行,医院抗菌药物使用明显规范,整治活动取得阶段性成效。OBJECTIVE To study the management and clinical application of antibiotics before and after carrying outthe special rectification campaign for clinical application of antibiotics so as to propose corresponding rectificationstrategies. METHODS The supply items of antibiotics were statistically analyzed six months before and after carrying out special rectification campaign,then the classified management of antibiotics, utilization rate of antibioticsof the hospitalized patients,density of use of antibiotics, proportion of prophylaxis antibiotics for type I incisionsurgery were observed. RESULTS There were 64 types of antibiotics with 97 dosage forms before the special rectification campaign was carried out, deceasing to 35 types with 64 dosage forms after the special rectification cam-paign was carried out. As compared with the usage of antibiotics before and after the special rectification campaignwas carried out, the proportion of antibiotics cost in drug expense decreased from 39. 43% to 29. 76%,the utilization rate of antibiotics of the hospitalized patients dropped from 83. 19% to 68. 32%,the use density decreasedfrom 96. 51 DDD to 51. 56 DDD, the proportion of combination use of antibiotics dropped from 48. 34% to27. 22% , the proportion of prophylaxis antibiotics for type I incision surgery decreased from 100. 00% to45. 37% , the drug administration proportion 0. 5-2 hours before the type I incision surgery increased from57. 15% to 89. 73%,the time of prophylactic use of antibiotics was shortened from 129. 61 h to 55. 28 h,the sub-mission rate of microorganism increased from 15. 40% to 26. 73%,and the utilization rate of antibiotics in the outpatient department dropped from 54.48% to 25. 27%. CONCLUSION The special rectification campaign can achieve substantive effectiveness through the implementation of policies, compliance to the formulated systems and measures, and the reasonable use of antibiotics.

关 键 词：限定日剂量 使用强度 Ⅰ类手术切口 

分 类 号：R978.1[医药卫生—药品]