祛痘类化妆品中违禁添加克林霉素的HPLC-DAD和LC-MS法检测  

Determination of Clindamycin Illegally Adulterated into Cosmetics for Acne Treatment by HPLC-DAD and LC-MS

作　　者：庞学斌[1] 于玥[1] 邱颖姮[1] 邬晓鸥[1] 黎俏美[1] 

机构地区：[1]深圳市药品检验所,广东深圳518057

出　　处：《中国医药工业杂志》2013年第9期935-937,共3页Chinese Journal of Pharmaceuticals

摘　　要：采用高效液相色谱-二极管阵列检测器和液相色谱-质谱联用仪检测祛痘类化妆品中违禁添加的克林霉素。克林霉素在0．01～2mg／ml浓度范围内线性良好，平均加样回收率为96．2％、98．5％和99．1％，RSD分别为3．0％、2．1％和1．3％。最低检出浓度为40μg／g。The HPLC-DAD and LC-MS methods were used to determine clindamycin added illegally in cosmetics for acne treatment. The calibration curve of clindamycin was linear in the concentration range of 0.01 - 2 mg/ml. The average recoveries were 96.2%, 98.5% and 99.1%, with RSDs of 3.0%, 2.1% and 1.3%. The limited detection concentration was 40 μg/g.

关 键 词：克林霉素 化妆品 高效液相色谱法 液相色谱-质谱联用 测定 

分 类 号：O657.72[理学—分析化学]