分布器类型及放大对扩张床装置流体动力学性能的影响及其在凝血酶原复合物吸附中的初步应用  

Effects of Type and Enlargement of Distributor on Hydrodynamics of Expanded Bed and Preliminary Application to Adsorption of Prothrombin Complex Concentrates

作　　者：李志雄[1] 赵红卫[1] 邱家山 何琦 李长清 

机构地区：[1]四川大学化学工程学院,四川成都610065 [2]成都英德生物工程有限公司,四川成都610045 [3]中蓝晨光化工研究院,四川成都610041 [4]中国医学科学院输血研究所,四川成都610052

出　　处：《中国医药工业杂志》2013年第9期943-947,共5页Chinese Journal of Pharmaceuticals

基　　金："863"计划项目(2012AA021903-3)

摘　　要：比较了在表观流速250 cm/h、沉降高度15 cm时,扩张床装置中25 mm规模的分布器种类(包括锥形和摇摆式)对流体动力学性能的影响。结果表明,摇摆式分布器效果较好(轴向混合系数D ax=3.8×10-6m2·s-1),将分布器规模放大至100 mm时D ax也能达到4.8×10-6m2·s-1。采用CG-6树脂在此两种扩张床装置中吸附人血浆中的凝血酶原复合物(PCC),结果测得PCC中4种凝血因子(FⅡ、FⅦ、FⅨ和FⅩ)的吸附率约90%,洗脱回收率约70%。The effects of distributor types （including tapered and rocking-type） at 25 mm scale of expanded bed on hydrodynamics were compared under the apparent flow rate of 250 cm/h and sinking height of 15 cm. The results showed that the device with rocking-type distributor had the optimal performance, which axial mixing coefficient （Dax） was 3.8×10-6m2s-1. When the rocking-type distributor was enlarged to 100 mm scale, the Dax could also reach 4.8×10-6m2s-1 The human plasma prothrombin complex concentrate （PCC） was adsorbed respectively with above two expanded bed with CG-6 resin. The results showed that the adsorption yields of four blood coagulation factors （F Ⅱ、FⅦ、FⅨ and FⅩ ） in PCC were about 90% and the recoveries by elution were about 70%.

关 键 词：扩张床 分布器 凝血酶原复合物 吸附 

分 类 号：TQ028[化学工程]