盐酸小檗碱对Ⅱ糖尿病血清视黄醇结合蛋白4水平的影响  

作　　者：刘坤[1] 曾玉琴[1] 

机构地区：[1]湖北省十堰市茅箭区人民医院内科,湖北十堰442000,

出　　处：《中国农村卫生》2013年第04Z期195-196,共2页

摘　　要：目的探讨Ⅱ糖尿病（T2DM）患者盐酸小檗碱治疗前后血清血清视黄醇结合蛋白4水平（RBP4）的变化。方法20例新诊断的T2DM患者经过饮食和运动治疗后血糖和糖化血红蛋白仍然不能达到茛好控制者，予盐酸小檗碱片0．9g／天口服治疗共16周，分别测定治疗前、后患者身高、体质量、腰围、臀围，测定空腹血糖（FBG）、总胆固醇（TC）、甘油三酯（TG）、游离脂肪酸（FFA）、空腹胰岛素（Fins）、糖化血红蛋白（HbAlc）、RBP水平。根据公式分别计算体重指数（BMI）、腰臀比（wHR）、胰岛素抵抗指数（Homa—IR）。结果T2DM患者予盐酸小檗碱治疗16周后BMI、wHR略低于治疗前，但差异无统计学意义，FPG、TC、TG、FFA、HbAlC、F1NS、RBP4、HOMR—IR水平均明显低于治疗前（P〈0．05-0．01），差异有统计学意义。结论盐酸小檗碱能明显降低T2DM患者的血糖、血脂水平，可能通过减少脂源性细胞因子RBP的分泌而减轻胰岛素抵抗。Objective To study the effect of herberine on the concentration of retinol binding protein 4（RBP4） in patients with type 2 diabetes mellitus （T2DM）. Methods 20 patients with newly T2DM whose fasting plasma glucose（FPG） and glycated hemoglobin（HbAlc） undercontrolled after diat and exercise conduction were enrolled in this study and were prescribed berberine（0.9g.d-1） for 16 weeks treatment. The height,weight,waist, hip were measured before and after treatment,and the serum was collected to examine the concentrations of FPG, total cholesterol（TC）, triglycerides （TG）, free fat acid （FFA）, fasting insulin （Fins）, glycated hemoglobin （HbAlc）, RBP4, and the body-- mass index （BMI）, the waist-- hip-- ratio （WHR） and HOMA--insulin resistance index（HOMA--IR） were calculated according to the famula. Results The BMI and WHR in this study after 16th treatment were lower than those before treatment, but there was not statistical difference. FPG,TC,TG,FFA, HbAIC,FINS, RBP4, HOMR-- IR were lower than those before treatment, there was statistical difference（P〈0. 05-0. 01） （P〈0.05）. Conclusion Berberine can decrease the ser- um plasma glucose and lipid in patients with T2DM,it may improve IR by decreasing the RBP4 secretion.

关 键 词：Ⅱ糖尿痛 盐酸小檗碱 血清视黄醇结合蛋白4 

分 类 号：R587.1[医药卫生—内分泌]