血清铁 铁蛋白及转铁蛋白联合检测在肝脏疾病中的应用  

Application of the combined detection of serum iron ferritin and transferrin in liver diseases

作　　者：范公忍[1] 周一鸣[1] 韩聚强[1] 胡学玲[1] 曹建彪[1] 

机构地区：[1]北京军区总医院全军肝病治疗中心,北京100700

出　　处：《检验医学与临床》2013年第16期2076-2077,2079,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨肝病患者铁代谢相关血清学指标的临床诊断意义及铁在肝损伤过程中的作用。方法采用全自动生化分析仪分别对52例慢性乙型肝炎患者,47例肝硬化患者,34例肝细胞癌患者和30例健康对照者进行血清Fe水平检测;采用电化学发光仪对慢性乙型肝炎患者、肝硬化和肝细胞癌患者及30例健康对照者进行血清铁蛋白及转铁蛋白检测。结果慢性乙型肝炎患者、肝硬化患者血清铁、铁蛋白水平均高于健康对照组(P<0.05);肝细胞癌患者铁蛋白、转铁蛋白及血清铁水平明显高于慢性乙型肝炎患者及肝硬化患者;与健康对照组比较差异有统计学意义(P<0.05)。肝病患者血清铁、铁蛋白和转铁蛋白与肝功能常用检测指标具有相关性。结论血清铁、铁蛋白和转铁蛋白可作为肝脏疾病诊断的重要参考指标,对疾病的判断和预后有重要的意义。Objective To investigate the clinical and diagnostic significance of the indicators related with iron metablism （serum iron,transferrin） and the role of serum iron in hapatic injury. Methods The Fe levels of 52 hepatitis B patients （chronic hepatitis group）, 47 patients with liver cirrhosis （liver cirrhosis group）, 34 patients with hepa tocellular carcinoma （HCC group） and 30 healthy subjects （control group） were determined by Hitachi 7170A auto matic biochemical analyzer. The serum ferritin（Ferr） and transferrin（TRF） levels in 4 groups were detected by chem iluminescent analyer（Roche）. Results Levels of Fe Ferr and TRF in chronic hepatitis group and liver cirrhosis group were higher than those in control group （P〈0.05） ; Hepatocellular carcinoma group the Ferr level and transferrin were higher than chronic hepatitis group and liver cirrhosis group,with statistical significance （P〈0.05）. there was significant correlation between serum iron, Serum ferritin, Serum transfensferrin and ALT, AST, ALE in patients with liver diseases. Conclusion Serum Fe,Ferr and TRF leverls could be important indices for predicting the degree of liver diseases, and have significance for diseases diagnosis and treatment.

关 键 词：肝脏疾病 血清铁 铁蛋白 转铁蛋白 

分 类 号：R587.2[医药卫生—内分泌]