基于厚朴七物汤及其母方对大鼠胃分泌功能的影响探讨合方的思想  

According the influence of Houpo Qiwu Decoction and its mother prescription on the function of rats,stomach to study compound prescription

作　　者：王昌儒[1,2] 

机构地区：[1]湖北中医药大学 [2]商丘市第一人民医院中医科

出　　处：《环球中医药》2013年第8期593-595,共3页Global Traditional Chinese Medicine

摘　　要：目的通过对厚朴七物汤与原母方间在功效上是否有相加、协同或拮抗作用的探讨,揭示"合方"中方与方间在主要功效方面可能存在的"增效"或"拮抗"关系。方法采用药理学方法,结合中药方剂的配合理论原则对厚朴七物汤及其母方厚朴三物汤与桂枝去芍药汤进行分析。结果桂枝去芍药汤与厚朴三物汤合方后,在保护胃黏膜方面,桂枝去芍药汤对厚朴三物汤产生了"增效"作用;桂枝去芍药汤与厚朴三物汤相合组成的厚朴七物汤,"先合后煎"的效果要优于"先煎后合"。结论桂枝去芍药汤减轻了厚朴三物汤对大鼠胃黏膜的损伤作用,即桂枝去芍药汤对厚朴三物汤的毒副作用是"相杀"关系,仲景合方中有"七情合和"的思想。Objective To study the additive effect,synergismor antagonism between Houpo Sanwu Decoction and Guizhi Qushaoyao Decoction in their compound prescription so as to confirm the possible pharmacodynamic actions（similar to seven actions related to compatibility of ingredients in compound prescription）.Methods Using the method of pharmacology and the principle of＂seven actions related to compatibility offing redients in a prescription＂of Chinese herbal medicine,the mutual effects between＂Houpo Sanwu Decoction and Guizhi Qushaoyao Decoction in their compound prescription was studied.Results The research revealed that the combination of Houpo Sanwu Decoction and Guizhi Qushaoyao Decoction is more effective protection in gastric mucosa.Conclusion Guizhi Qushaoyao Decoction mitigate Houpo Sanwu Decoction injury of gastric mucosa,this is ＂xiangsha＂,In Zhangzhongjing,s compound prescriptions have the idea of＂Qiqinghehe＂.

关 键 词：合方 厚朴三物汤 厚朴七物汤 桂枝去芍药汤 

分 类 号：R289[医药卫生—方剂学]