纳洛酮的药理特性及其在麻醉镇痛中的应用  

Pharmacological Action of Naloxone and Its Application in Anesthesia Analgesia

作　　者：尹柏双[1,2] 付连军[1] 宋永利[1] 骆艳秋[1] 高利[2] 王洪斌[2] 

机构地区：[1]吉林农业科技学院动物医学学院,吉林吉林132101 [2]东北农业大学动物医学学院,黑龙江哈尔滨150030

出　　处：《安徽农业科学》2013年第18期7822-7823,7837,共3页Journal of Anhui Agricultural Sciences

基　　金：国家自然科学基金项目(31272617;30972227);长白山动植物资源保护与利用省级重点实验室基金项目(吉农院合字2012701);吉林农业科技学院博士启动基金项目(吉农院合字2012307);吉林农业科技学院种子基金项目(吉农院合字2013905);吉林农业科技学院储备基金项目(吉农院合字2012406)

摘　　要：纳洛酮是一种阿片受体颉颃剂,可快速逆转阿片受体激动剂引起的镇静和麻醉,被国外兽医广泛应用于阿片受体激动剂诱导动物镇静和麻醉后的苏醒,或与其他药物联合应用于临床疾病的治疗。从纳洛酮的药理作用及在动物麻醉方面的应用进行阐述,旨在为该药物在国内兽医临床的合理应用提供参考。Naloxone was an opioid receptor anti-agonist,could reverse quickly anesthesia and sedation produced by opioid receptor agonist.It was used universally to analepsia animals that were induced by opioid receptor agonist.Naloxone could be also combined with other drugs applying to treat diseases.The pharmacological action of naloxone and application in anesthesia analgesia was elaborated,which will provide a reference for domestic veterinary clinic application.

关 键 词：纳洛酮 药理作用 麻醉 应用 

分 类 号：S852.2[农业科学—基础兽医学]