呼吸气体的直接质谱分析  

Analysis of Breathing Gas by Direct Mass Spectrometry Techniques

作　　者：王海东[1] 潘素素[1] 张燕[1] 屈颖[1] 韩超 陈焕文[1] 

机构地区：[1]东华理工大学/江西省质谱科学与仪器重点实验室,江西南昌330013 [2]温州出入境检验检疫局,浙江温州325027

出　　处：《现代科学仪器》2013年第4期40-45,共6页Modern Scientific Instruments

基　　金：江西省科技支撑计划项目(2010BSA10200);国家质检总局科技项目(2011IK248);浙江省科技厅公益项目(2011C23120)资助

摘　　要：呼吸气体携带重要的人体生理/病理状态的信息,且具有非侵入性、无创、方便、连续可得等特点,受到相关研究人员越来越多的重视。呼吸气体的检测在代谢组学、临床医学、安全卫生等领域中具有重要意义。同传统的色谱质谱检测技术相比,直接质谱分析技术在呼吸气体的检测中具有高灵敏度、高选择性、低损耗的特点,真正达到了实时在线、原位活体分析的要求。本文介绍了质子转移反应质谱(PTR-MS)、选择离子流动管质谱(SIFT-MS)以及电喷雾萃取电离质谱(EESI-MS)三种直接质谱分析方法的原理及其在呼吸气体检测中的应用实例,并展望了呼吸气体检测的应用前景和发展方向。Breathing gas is receiving more and more attentions from researchers for the important physiological/ pathological information it carries,and its non-invasive,conveniently and continuously available nature.Detection of breathing gas is very important in studying the mechanism of human metabolism,clinical medicine,health and safety.Compared to traditional chromatography-mass spectrometry detection,direct mass spectrometric analysis for detecting breathing gas is a real-time,online and in-vivo technique with high sensitivity and low-loss requirements.In this article,we reviewed three kinds of direct mass spectrometry techniques：proton transfer reaction mass spectrometry（PTR-MS）,selected ion flow tube mass spectrometry（SIFT-MS）,and the extractive electrospray ionization mass spectrometry（EESI-MS） with their applications breathing gas detection.We also discussed the prospects and development of breathing gas detection.

关 键 词：呼吸气体 质子转移反应质谱 选择离子流动管质谱 电喷雾萃取电离质谱 

分 类 号：R446.1[医药卫生—诊断学] O657.63[医药卫生—临床医学]