初发急性心肌梗死血浆B型脑钠肽的研究  

Study on B-type natriuretic peptide in primary acute myocardial infarction

作　　者：杨庆业[1] 蒋一鸣 俎德玲[1] 诸葛毅[2] 屠晓鸣[1] 金奇志[1] 

机构地区：[1]浙江省衢州市人民医院心血管内科,浙江衢州324000 [2]衢州学院,浙江衢州324000

出　　处：《中国卫生检验杂志》2013年第10期2253-2255,共3页Chinese Journal of Health Laboratory Technology

基　　金：衢州市科技局课题项目(20090327132024525)

摘　　要：目的研究初发AMI后BNP的变化。方法入选115例初发AMI患者,入院24 h内测定血浆BNP浓度、LVEF、LVIDd等指标,按ST段是否抬高分为STEMI组、NSTEMI组,STEMI组再分为不同梗死部位组,所有AMI按是否行急诊再灌注治疗分为急诊再灌注治疗组、非急诊再灌注治疗组,根据冠脉造影结果分为单支血管病变组、双支血管病变组、三支及左主干病变组,比较不同组间BNP及其它上述参数的变化。结果AMI急性期血BNP明显升高,但在STEMI组与NSTEMI组间无差异。AMI患者行急诊PCI及药物静脉溶栓治疗组BNP水平明显低于未行急诊再灌注治疗组(P<0.05)。3支或左主干病变、2支病变患者BNP水平均显著高于单支病变(P<0.01),3支或左主干病变BNP水平又高于双支病变(P<0.01)。结论 BNP有助于评估初发急性心梗冠脉病变严重程度。Objective To study the B - type plasma brain natriuretic peptide （BNP） level changes after the initial onset of acute myocardial infarction （AMI） . Methods A total of 115 primary AMI patients were selected to deter- mine the plasma BNP level, LVEF and LVIDd in 24 h, and in accordance with the elevation of ST, the 115 cases were divided into STEMI group and NSTEMI group, and STEM/-were subdivided into different groups according to infarction location. All AMI patients were divided into emergency reperfusion group and non - emergency reperfusion group. According to the coronary angiography results, all these cases were divided into single vessel disease group, double vessel disease group, triple vessel disease group and left main coronary disease group. BNP level and the a- bove parameters were compared among groups. Results BNP increased significantly in AMI patients, but there was no difference between STEMI group and NSTEMI group. AMI patients undergoing emergency PCI and drug in- travenous thrombolytic therapy had lower BNP level than that of non - emergency reperfusion group （ P 〈 0.05 ）. BNP level from high to low was Triple vessel disease or left main coronary disease group, double vessel disease group, single vessel disease group （P 〈0. 01 ）. Condution BNP is helpful to evaluate the severity of primary a- cute myocardial infarction coronary lesion.

关 键 词：BNP 急性心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]